Graphene Oxide-Gold Nanorods Nanocomposite-Porphyrin Conjugate as Promising Tool for Cancer Phototherapy Performance

被引：13

作者：

Lebepe, Thabang Calvin ^{[1
,2
]}

Parani, Sundararajan ^{[1
,2
]}

Ncapayi, Vuyelwa ^{[1
,2
]}

Maluleke, Rodney ^{[1
,2
]}

Mbaz, Grace It Mwad ^{[1
,2
]}

Fanoro, Olufunto Tolulope ^{[2
]}

Varghese, Jose Rajendran ^{[1
,2
]}

Komiya, Atsuki ^{[3
]}

Kodama, Tetsuya ^{[4
]}

Oluwafemi, Oluwatobi Samuel ^{[1
,2
]}

机构：

[1] Univ Johannesburg, Dept Chem Sci, ZA-2028 Johannesburg, South Africa

[2] Univ Johannesburg, Ctr Nanomat Sci Res, ZA-2028 Johannesburg, South Africa

[3] Tohoku Univ, Inst Fluid Sci, Sendai, Miyagi 9808577, Japan

[4] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi 9808575, Japan

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 12期

基金：

新加坡国家研究基金会; 芬兰科学院;

关键词：

graphene oxide; gold nanorods; TMePyP; photothermal; singlet oxygen; cytotoxicity; SURFACE FUNCTIONALIZATION; PHOTODYNAMIC THERAPY; SYNERGISTIC THERAPY; COLLOIDAL STABILITY; PHOTOSENSITIZER; IMPACT;

D O I：

10.3390/ph14121295

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cancer mortality rate has increased, and conventional cancer treatments are known for having many side effects. Therefore, it is imperative to find a new therapeutic agent or modify the existing therapeutic agents for better performance and efficiency. Herein, a synergetic phototherapeutic agent based on a combination of photothermal and photodynamic therapy is proposed. The phototherapeutic agent consists of water-soluble cationic porphyrin (5,10,15,20-tetrakis(N-methylpyridinium-3-yl)porphyrin, TMePyP), and gold nanorods (AuNRs) anchored on graphene-oxide (GO) sheet. The TMePyP was initially synthesized by Adler method, followed by methylation, while GO and AuNRs were synthesized using Hummer's and seed-mediated methods, respectively. The structural and optical properties of TMePyP were confirmed using UV-Vis, zeta analyzer, PL, FTIR and NMR. The formation of both GO and AuNRs was confirmed by UV-Vis-NIR, FTIR, TEM and zeta analyzer. TMePyP and AuNRs were anchored on GO to form GO@AuNRs-TMePyP nanocomposite. The as-synthesized nanocomposite was stable in RPMI and PBS medium, and, on irradiation, produced high heat than the bare AuNRs, with high photothermal efficiency. In addition, the nanocomposite produced higher singlet oxygen than TMePyP with high biocompatibility in the absence of light. These results indicated that the as-synthesized nanocomposite is a promising dual photodynamic and photothermal agent for cancer therapy.

引用

页数：16

共 50 条

[1] Polydopamine-tailored paclitaxel-loaded polymeric microspheres with adhered NIR-controllable gold nanoparticles for chemo-phototherapy of pancreatic cancer [J].