The Prognostic Significance of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients With Multiple Myeloma

被引：46

作者：

Wongrakpanich, Supakanya ^{[1
]}

George, Gemlyn ^{[1
]}

Chaiwatcharayut, Wikrom ^{[1
]}

Biso, Sylvia ^{[1
]}

Candelario, Nellowe ^{[1
]}

Mittal, Varun ^{[1
]}

Pomerantz, Sherry ^{[1
]}

Varadi, Gabor ^{[1
]}

机构：

[1] Einstein Med Ctr, Med, Philadelphia, PA USA

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2016年 / 30卷 / 06期

关键词：

multiple myeloma; neutrophil-to-lymphocyte ratio; overall survival; platelet-to-lymphocyte ratio; prognostic marker; SURVIVAL; DIAGNOSIS; LYMPHOPENIA; THERAPY;

D O I：

10.1002/jcla.22004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

ObjectNeutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, inexpensive prognostic markers for various conditions. The objective of this study was to determine the prognostic significance of NLR and PLR in patients with multiple myeloma (MM) in terms of survival. MethodA retrospective chart review study was conducted for 175 patients who met the criterion of diagnosis for MM between January 2004 and September 2014. ResultThe median age of diagnosis was 69 years. Patients were divided into high and low NLR and PLR groups according to cutoff points from the receiver operating characteristic curve (2.78 and 155.58, respectively). The high NLR and PLR groups were associated with lower albumin level and higher staging. The high NLR group experienced inferior median survival compared with the low NLR group (37 vs. 66 months; log-rank P-value 0.005). However, there was no significant difference in median survival between the high and low PLR groups (45 vs. 62 months; P = 0.077). Multivariate analysis demonstrated that NLR is an independent predictor for OS of MM (HR 2.892; P = 0.009). ConclusionWe conclude that NLR is an independent prognostic factor for OS in MM.

引用

页码：1208 / 1213

页数：6

共 28 条

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