The effect of calcium channels blockers in the K+-evoked release of [3H]adenine nucleotides from rat brain cortical synaptosomes

被引：2
|
作者：
Mesquita, F
Prado, MAM
Gomez, RS
Romano-Silva, MA
Gomez, MV
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, BR-30270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, BR-30270901 Belo Horizonte, MG, Brazil
来源：
NEUROSCIENCE LETTERS | 1998年 / 258卷 / 01期
关键词：
adenine nucleotides release; calcium channels; K+-induced; brain synaptosomes;
D O I：
10.1016/S0304-3940(98)00837-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The role of L-,N-, P- and Q-type voltage-dependent calcium channels in K+-induced release of [H-3]adenine nucleotides from rat brain cortical synaptosomes was investigated. Cd2+, a non-specific blocker of calcium channels, inhibited by 69% the release of the nucleotides induced by 33 mM K+. Nifedipine, omega-Gonotoxin GVIA and omega-Agatoxin IVA had no effect whereas omega-Conotoxin MVIIC inhibited by 62% the K+ induced release of adenine nucleotides in Pat brain cortical synaptosomes. It is concluded that Q-type calcium channels are directly involved in the release of adenine nucleotides in rat brain cortical synaptosomes. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：57 / 59
页数：3
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