Oligonucleotides bearing 5-formyl-2′-0-methyluridine:: Preference in binding affinity to the NF-κB (p50)2 homo- and p50/p65 heterodimers

被引：14
作者：
Kittaka, A
Kuze, T
Asakura, T
Ito, K
Miyasaka, T
Inoue, J
机构：
[1] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 1428555, Japan
[2] Univ Tokyo, Inst Med Sci, Dept Oncol, Minato Ku, Tokyo 1088639, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期
关键词：
D O I：
10.1016/S0960-894X(98)00584-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：3207 / 3210
页数：4
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