A metal-free aromatic cascade for the synthesis of diverse heterocycles

被引：10
作者：
Schlitzer, Steven C. [1 ,2 ]
Arunprasath, Dhanarajan [1 ,2 ]
Stevens, Katelyn G. [1 ,2 ]
Sharma, Indrajeet [1 ,2 ]
机构：
[1] Univ Oklahoma, Dept Chem & Biochem, 101 Stephenson Pkwy, Norman, OK 73071 USA
[2] Univ Oklahoma, Inst Nat Prod Applicat & Res Technol, 101 Stephenson Pkwy, Norman, OK 73071 USA
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 07期
关键词：
STEREOSELECTIVE-SYNTHESIS; ELECTROCYCLIC REACTIONS; KETENES; REACTIVITY; CATALYSIS; ANALOGS; YLIDES; ACCESS; STILLE;
D O I：
10.1039/c9qo01336a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free aromatic cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade is initiated by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6 pi-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.
引用
收藏
页码：913 / 918
页数：6
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