A metal-free aromatic cascade for the synthesis of diverse heterocycles

被引：11

作者：

Schlitzer, Steven C. ^{[1
,2
]}

Arunprasath, Dhanarajan ^{[1
,2
]}

Stevens, Katelyn G. ^{[1
,2
]}

Sharma, Indrajeet ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, 101 Stephenson Pkwy, Norman, OK 73071 USA

[2] Univ Oklahoma, Inst Nat Prod Applicat & Res Technol, 101 Stephenson Pkwy, Norman, OK 73071 USA

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 07期

关键词：

STEREOSELECTIVE-SYNTHESIS; ELECTROCYCLIC REACTIONS; KETENES; REACTIVITY; CATALYSIS; ANALOGS; YLIDES; ACCESS; STILLE;

D O I：

10.1039/c9qo01336a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free aromatic cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade is initiated by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6 pi-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.

引用

页码：913 / 918

页数：6

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