Synthesis and Antimicrobial Activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl)-2-(Pyridine-2-ylamino)ethanone

被引：0
|
作者：
Salimon, Jumat [1 ]
Salih, Nadia [1 ]
Hussien, Hasan [2 ]
机构：
[1] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Chem Sci & Food Technol, Bangi Selangor De 43600, Malaysia
[2] Al Nahrain Univ, Coll Sci, Dept Chem, Baghdad, Iraq
来源：
SAINS MALAYSIANA | 2011年 / 40卷 / 05期
关键词：
1,3,4-oxadiazoles compound; antimicrobial activity; hydrazide acid; DERIVATIVES;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
1-(5-Mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone (3), has been synthesized from 2-(pyridine-2-ylamino)acetohydrazide (2). A yellow colored compound (2) was reacted with carbon disulfide and potassium hydroxide in absolute ethanol to obtain the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino) ethanone. Structures of the synthesized compounds were supported by means of IR, NMR, MS spectroscopic and elemental analysis. The synthesized compounds were evaluated for their antimicrobial activity and were expressed as the corresponding minimum inhibitory concentration (MIC). A brown colored compound (3) with 90% yield has been successfully synthesized. This compound was found to have significant antimicrobial activity with MIC value ranging from 30.2 - 43.2 mu g cm(-3). The findings of the present study indicate that cyclization of hydrazide acid group of 2-(pyridine-2-ylamino)acetohydrazide (2) into 1,3,4-oxadiazole nucleus resulted in increased antimicrobial activity.
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收藏
页码：445 / 450
页数：6
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