Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives

被引：5

作者：

Robinson, Tanisha M. ^{[1
,5
]}

Jicsinszky, Laszlo ^{[1
,2
]}

Karginov, Andrei V. ^{[3
]}

Karginov, Vladimir A. ^{[1
,4
]}

机构：

[1] Innovat Biol Inc, Herndon, VA USA

[2] Univ Turin, Dipartimento Sci & Tecnol Farm, Turin, Italy

[3] Univ Illinois, Dept Pharmacol, Chicago, IL 60680 USA

[4] KFBio LLC, 43136 Fling Ct, Ashburn, VA 20148 USA

[5] Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2017年 / 531卷 / 02期

基金：

美国国家卫生研究院;

关键词：

beta-cyclodextrin derivatives; Toxin inhibitors; Clostridium perfringens; epsilon-toxin; Bacillus anthracis; Lethal toxin; PORE; MOLECULE; DISEASES; ANIMALS;

D O I：

10.1016/j.ijpharm.2017.07.070

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clostridium perfringens epsilon toxin (ETX) is considered as one of the most dangerous potential biological weapons. The goal of this work was to identify inhibitors of ETX using a novel approach for the inactivation of pore-forming toxins. The approach is based on the blocking of the target pore with molecules having the same symmetry as the pore itself. About 200 various beta-cyclodextrin derivatives were screened for inhibitors of ETX activity using a colorimetric cell viability assay. Several compounds with dose-dependent activities at low micromolar concentrations have been identified. The same compounds were also able to inhibit lethal toxin of Bacillus anthracis. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：714 / 717

页数：4

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