Comparison of genomic DNA sequences: solved and unsolved problems

被引：79

作者：

Miller, W ^{[1
]}

机构：

[1] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA

来源：

BIOINFORMATICS | 2001年 / 17卷 / 05期

关键词：

D O I：

10.1093/bioinformatics/17.5.391

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: The DNA sequences of entire genomes are being determined at a rapid rate. Whereas initial genome sequencing efforts were for organisms chosen to be widely spaced in the tree of life, there is a growing emphasis on projects to sequence a species that is sufficiently similar to an already-sequenced species to allow direct comparison of those two DNA sequences. This and other changes in genome sequencing strategies have created a strong need for new methods to compare genomic sequences. Results: We sketch the current state of software for comparing genomic DNA sequences and outline research directions that we believe are likely to result in important advances in practice.

引用

页码：391 / 397

页数：7

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