The role of proteases during apoptosis

被引：528
作者：
Patel, T
Gores, GJ
Kaufmann, SH
机构：
[1] MAYO CLIN & MAYO FDN,MAYO MED SCH,CTR BASIC RES DIGEST DIS,DIV GASTROENTEROL,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO FDN,DIV ONCOL RES,ROCHESTER,MN 55905
[3] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN 55905
来源：
FASEB JOURNAL | 1996年 / 10卷 / 05期
关键词：
calpains; granzymes; interleukin-1 beta converting enzyme; programmed cell death; serine protease inhibitors; ubiquitin;
D O I：
10.1096/fasebj.10.5.8621058
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The importance of proteases during apoptosis is becoming increasingly apparent, Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic: strategies, In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.
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收藏
页码：587 / 597
页数：11
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