Mechanical and biological response of (CeO2+La2O3)-substituted 45S5 bioactive glasses for biomedical application

In the present study, bioactive glasses of specific compositional formula (45-X) SiO2, 24.5 Na2O, 24.5 CaO, and 6 P2O5 (wt%) were made by substitute of X = (0.0, 0.5, 1.0, 1.5, and 2.0) equal wt% of CeO2 and La2O3. The mixed homogeneous glass powder melted in a platinum crucible at the furnace temperature of 1400 +/- 5 degrees C with air as a furnace environment. Synthesized novel Bioglass (R) was further characterized for in vitro bioactivity and physicomechanical properties. Microstructures of developed glass samples were evaluated by SEM. Bioactivity of glass samples was assessed in simulated body fluid (SBF) for different time intervals and it was evaluated using XRD, FTIR, and SEM. Furthermore, the substitution of CeO2 and La2O3 in the base glass enhances its cytocompatibility and cell supportive properties. Also, microhardness and flexural strength of base Bioglass (R) was enhanced with the incorporation of CeO2 and La2O3 and resulted in increasing density of doped glass. Thus, the developed CeO2 and La2O3-incorporated bioactive glasses with superior mechanical properties have higher density and superior mechanical properties which make these bioactive glasses a suitable candidate for bone implant application.