Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

被引：211

作者：

Dhar, Mahesh S. ^{[1
]}

Marwal, Robin ^{[1
]}

Radhakrishnan, V. S. ^{[1
]}

Ponnusamy, Kalaiarasan ^{[1
]}

Jolly, Bani ^{[2
,3
]}

Bhoyar, Rahul C. ^{[2
]}

Sardana, Viren ^{[2
,3
]}

Naushin, Salwa ^{[2
,3
]}

Rophina, Mercy ^{[2
,3
]}

Mellan, Thomas A. ^{[4
]}

Mishra, Swapnil ^{[4
]}

Whittaker, Charles ^{[4
]}

Fatihi, Saman ^{[2
,3
]}

Datta, Meena ^{[1
]}

Singh, Priyanka ^{[1
]}

Sharma, Uma ^{[1
]}

Ujjainiya, Rajat ^{[2
,3
]}

Bhatheja, Nitin ^{[2
]}

Divakar, Mohit Kumar ^{[2
,3
]}

Singh, Manoj K. ^{[1
]}

Imran, Mohamed ^{[2
,3
]}

Senthivel, Vigneshwar ^{[2
,3
]}

Maurya, Ranjeet ^{[2
,3
]}

Jha, Neha ^{[2
]}

Mehta, Priyanka ^{[2
]}

Vivekanand, A. ^{[2
,3
]}

Sharma, Pooja ^{[2
,3
]}

Arvinden, V. R. ^{[2
,3
]}

Chaudhary, Urmila ^{[1
]}

Soni, Namita ^{[1
]}

Thukral, Lipi ^{[2
,3
]}

Flaxman, Seth ^{[5
]}

Bhatt, Samir ^{[4
,6
]}

Pandey, Rajesh ^{[2
,3
]}

Dash, Debasis ^{[2
,3
]}

Faruq, Mohammed ^{[2
,3
]}

Lall, Hemlata ^{[1
]}

Gogia, Hema ^{[1
]}

Madan, Preeti ^{[1
]}

Kulkarni, Sanket ^{[1
]}

Chauhan, Himanshu ^{[1
]}

Sengupta, Shantanu ^{[2
,3
]}

Kabra, Sandhya ^{[1
]}

Gupta, Ravindra K. ^{[7
,8
]}

Singh, Sujeet K. ^{[1
]}

Agrawal, Anurag ^{[2
,3
]}

Rakshit, Partha ^{[1
]}

机构：

[1] Natl Ctr Dis Control, Delhi, India

[2] CSIR Inst Genom & Integrat Biol, New Delhi, India

[3] Acad Sci & Innovat Res, Ghaziabad, India

[4] Imperial Coll London, Med Res Council MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, Jameel Inst, London, England

[5] Imperial Coll London, Dept Math, London, England

[6] Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, Copenhagen, Denmark

[7] Univ Cambridge, Cambridge Inst Therapeut Immunol & Infect Dis CIT, Dept Med, Cambridge, England

[8] Africa Hlth Res Inst, Kwa Zulu, South Africa

来源：

SCIENCE | 2021年 / 374卷 / 6570期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

HEALTH-CARE WORKERS; POPULATION;

D O I：

10.1126/science.abj9932

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

引用

页码：995 / +

页数：29

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