Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion

被引：7
作者：
Zhang, Xiu-Zhong [1 ]
Li, Fu-Huang [2 ]
Wang, Xiao-Jia [1 ]
机构：
[1] China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol, Minist Agr, Beijing, Peoples R China
[2] Beijing Gen Stn Anim Husb Serv, South Sect, Beijing, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
TRIM proteins; type I interferon; NF-kappa B; immune evasion; signaling pathways; immune response; TRIM FAMILY PROTEINS; NF-KAPPA-B; TLR3/4-MEDIATED INNATE IMMUNE; PATTERN-RECOGNITION RECEPTORS; IFN-BETA PRODUCTION; RIG-I; RETROVIRAL RESTRICTION; DEPENDENT DEGRADATION; NEGATIVE REGULATION; ANTIVIRAL RESPONSE;
D O I：
10.3389/fmicb.2021.794882
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells. TRIMs play important roles in modulating signaling pathways of antiviral immune responses via type I interferon, NF-kappa B, Janus kinase/signal transducer and activator of transcription (JAK/STAT), and Nrf2. However, viruses are able to antagonize TRIM activity or evenly utilize TRIMs for viral replication. This communication presents the current understanding of TRIMs exploited by viruses to evade host immune response.
引用
收藏
页数：12
相关论文
共 132 条
  • [11] RIG-I-like receptor regulation in virus infection and immunity
    Chan, Ying Kai
    Gack, Michaela U.
    [J]. CURRENT OPINION IN VIROLOGY, 2015, 12 : 7 - 14
  • [12] Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling
    Chang, Chi-You
    Liu, Helene Minyi
    Chang, Ming-Fu
    Chang, Shin C.
    [J]. JOURNAL OF VIROLOGY, 2020, 94 (13)
  • [13] Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins
    Chelbi-Alix, MK
    de Thé, H
    [J]. ONCOGENE, 1999, 18 (04) : 935 - 941
  • [14] Fish-specific finTRIM FTR36 triggers IFN pathway and mediates inhibition of viral replication
    Chen, Bo
    Huo, Shitian
    Liu, Wanmeng
    Wang, Fang
    Lu, Yuanan
    Xu, Zhen
    Liu, Xueqin
    [J]. FISH & SHELLFISH IMMUNOLOGY, 2019, 84 : 876 - 884
  • [15] Promyelocytic leukemia restricts enterovirus 71 replication by inhibiting autophagy
    Chen, Deyan
    Feng, Chunhong
    Tian, Xiaoyan
    Zheng, Nan
    Wu, Zhiwei
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [16] Gene expression profiling of the TRIM protein family reveals potential biomarkers for indicating tuberculosis status
    Chen, Yanqing
    Cao, Shuhui
    Sun, Yong
    Li, Chuanyou
    [J]. MICROBIAL PATHOGENESIS, 2018, 114 : 385 - 392
  • [17] The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability
    Chiang, Cindy
    Dvorkin, Steve
    Chiang, Jessica J.
    Potter, Rachel B.
    Gack, Michaela U.
    [J]. MBIO, 2021, 12 (02):
  • [18] The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling
    Chiang, Cindy
    Pauli, Eva-Katharina
    Biryukov, Jennifer
    Feister, Katharina F.
    Meng, Melissa
    White, Elizabeth A.
    Munger, Karl
    Howley, Peter M.
    Meyers, Craig
    Gack, Michaela U.
    [J]. JOURNAL OF VIROLOGY, 2018, 92 (06)
  • [19] Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity
    Chiang, Jessica J.
    Sparrer, Konstantin M. J.
    van Gent, Michiel
    Laessig, Charlotte
    Huang, Teng
    Osterrieder, Nikolaus
    Hopfner, Karl-Peter
    Gack, Michaela U.
    [J]. NATURE IMMUNOLOGY, 2018, 19 (01) : 53 - +
  • [20] Severe Fever with Thrombocytopenia Syndrome Virus NSs Interacts with TRIM21 To Activate the p62-Keap1-Nrf2 Pathway
    Choi, Younho
    Jiang, Zhongyi
    Shin, Woo-Jin
    Jung, Jae U.
    [J]. JOURNAL OF VIROLOGY, 2020, 94 (06)
12345678910