Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion

被引：8

作者：

Zhang, Xiu-Zhong ^{[1
]}

Li, Fu-Huang ^{[2
]}

Wang, Xiao-Jia ^{[1
]}

机构：

[1] China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol, Minist Agr, Beijing, Peoples R China

[2] Beijing Gen Stn Anim Husb Serv, South Sect, Beijing, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

TRIM proteins; type I interferon; NF-kappa B; immune evasion; signaling pathways; immune response; TRIM FAMILY PROTEINS; NF-KAPPA-B; TLR3/4-MEDIATED INNATE IMMUNE; PATTERN-RECOGNITION RECEPTORS; IFN-BETA PRODUCTION; RIG-I; RETROVIRAL RESTRICTION; DEPENDENT DEGRADATION; NEGATIVE REGULATION; ANTIVIRAL RESPONSE;

D O I：

10.3389/fmicb.2021.794882

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells. TRIMs play important roles in modulating signaling pathways of antiviral immune responses via type I interferon, NF-kappa B, Janus kinase/signal transducer and activator of transcription (JAK/STAT), and Nrf2. However, viruses are able to antagonize TRIM activity or evenly utilize TRIMs for viral replication. This communication presents the current understanding of TRIMs exploited by viruses to evade host immune response.

引用

页数：12

共 132 条

[91] The B30.2(SPRY) domain of the retroviral restriction factor TRIM5α exhibits line age-specific length and sequence variation in primates [J].

Song, BW ;

Gold, B ;

O'hUigin, C ;

Javanbakht, H ;

Li, X ;

Stremlau, M ;

Winkler, C ;

Dean, M ;

Sodroski, J .

JOURNAL OF VIROLOGY, 2005, 79 (10) :6111-6121

[92] HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome [J].

Song, Yinjing ;

Wu, Xia ;

Xu, Yaohan ;

Zhu, Jiang ;

Li, Jiaying ;

Zou, Ziqi ;

Chen, Luxia ;

Zhang, Boya ;

Hua, Chunting ;

Rui, Han ;

Zheng, Qiaoli ;

Zhou, Qiang ;

Wang, Qingqing ;

Cheng, Hao .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (15) :2924-2937

[93] The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response [J].

Soulat, Didier ;

Buerckstuemmer, Tilmann ;

Westermayer, Sandra ;

Goncalves, Adriana ;

Bauch, Angela ;

Stefanovic, Adrijana ;

Hantschel, Oliver ;

Bennett, Keiryn L. ;

Decker, Thomas ;

Superti-Furga, Giulio .

EMBO JOURNAL, 2008, 27 (15) :2135-2146

[94] TRIM23 mediates virus-induced autophagy via activation of TBK1 [J].

Sparrer, Konstantin M. J. ;

Gableske, Sebastian ;

Zurenski, Matthew A. ;

Parker, Zachary M. ;

Full, Florian ;

Baumgart, Gavin J. ;

Kato, Jiro ;

Pacheco-Rodriguez, Gustavo ;

Liang, Chengyu ;

Pornillos, Owen ;

Moss, Joel ;

Vaughan, Martha ;

Gack, Michaela U. .

NATURE MICROBIOLOGY, 2017, 2 (11) :1543-1557

[95] TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages [J].

Su, Xiaomin ;

Zhang, Qianjing ;

Yue, Jianmei ;

Wang, Yachen ;

Zhang, Yuan ;

Yang, Rongcun .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 89

[96] Dengue virus activates cGAS through the release of mitochondrial DNA [J].

Sun, Bo ;

Sundstrom, Karin B. ;

Chew, Jun Jie ;

Bist, Pradeep ;

Gan, Esther S. ;

Tan, Hwee Cheng ;

Goh, Kenneth C. ;

Chawla, Tanu ;

Tang, Choon Kit ;

Ooi, Eng Eong .

SCIENTIFIC REPORTS, 2017, 7

[97] TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2 [J].

Sun, Nan ;

Jiang, Li ;

Ye, Miaomiao ;

Wang, Yihan ;

Wang, Guangwen ;

Wan, Xiaopeng ;

Zhao, Yuhui ;

Wen, Xia ;

Liang, Libin ;

Ma, Shujie ;

Liu, Liling ;

Bu, Zhigao ;

Chen, Hualan ;

Li, Chengjun .

PROTEIN & CELL, 2020, 11 (12) :894-914

[98] Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight [J].

Sundquist, Wesley I. ;

Pornillos, Owen .

CELL HOST & MICROBE, 2018, 24 (06) :751-753

[99] Pattern Recognition Receptors and Inflammation [J].

Takeuchi, Osamu ;

Akira, Shizuo .

CELL, 2010, 140 (06) :805-820

[100] Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling [J].

Tan, Peng ;

He, Lian ;

Cui, Jun ;

Qian, Chen ;

Cao, Xin ;

Lin, Meng ;

Zhu, Qingyuan ;

Li, Yinyin ;

Xing, Changsheng ;

Yu, Xiao ;

Wang, Helen Y. ;

Wang, Rong-Fu .

MOLECULAR CELL, 2017, 68 (02) :293-+

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