Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion

被引：7
作者：
Zhang, Xiu-Zhong [1 ]
Li, Fu-Huang [2 ]
Wang, Xiao-Jia [1 ]
机构：
[1] China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol, Minist Agr, Beijing, Peoples R China
[2] Beijing Gen Stn Anim Husb Serv, South Sect, Beijing, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
TRIM proteins; type I interferon; NF-kappa B; immune evasion; signaling pathways; immune response; TRIM FAMILY PROTEINS; NF-KAPPA-B; TLR3/4-MEDIATED INNATE IMMUNE; PATTERN-RECOGNITION RECEPTORS; IFN-BETA PRODUCTION; RIG-I; RETROVIRAL RESTRICTION; DEPENDENT DEGRADATION; NEGATIVE REGULATION; ANTIVIRAL RESPONSE;
D O I：
10.3389/fmicb.2021.794882
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells. TRIMs play important roles in modulating signaling pathways of antiviral immune responses via type I interferon, NF-kappa B, Janus kinase/signal transducer and activator of transcription (JAK/STAT), and Nrf2. However, viruses are able to antagonize TRIM activity or evenly utilize TRIMs for viral replication. This communication presents the current understanding of TRIMs exploited by viruses to evade host immune response.
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页数：12
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