Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia

被引：42

作者：

Kubicki, Marek ^{[1
,2
]}

Alvarado, Jorge L. ^{[1
]}

Westin, Carl-Fredrik ^{[3
]}

Tate, David F. ^{[4
,5
,6
]}

Markant, Douglas ^{[1
]}

Terry, Douglas P. ^{[1
]}

Whitford, Thomas J. ^{[1
,7
,8
]}

De Siebenthal, Julien ^{[1
]}

Bouix, Sylvain ^{[1
]}

McCarley, Robert W. ^{[2
]}

Kikinis, Ron ^{[9
]}

Shenton, Martha E. ^{[1
,2
,9
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab,Med Sch, Boston, MA 02215 USA

[2] Harvard Univ, Boston VA Healthcare Syst Brockton Div, Dept Psychiat, Clin Neurosci Div,Lab Neurosci,Med Sch, Boston, MA 02215 USA

[3] Harvard Univ, Brigham & Womens Hosp, Dept Radiol, Lab Math Imaging,MRI Div,Med Sch, Boston, MA 02215 USA

[4] Harvard Univ, Brigham & Womens Hosp, Ctr Neurol Imaging, Dept Radiol,Med Sch, Boston, MA 02215 USA

[5] Harvard Univ, Brigham & Womens Hosp, Ctr Neurol Imaging, Dept Psychiat,Med Sch, Boston, MA 02215 USA

[6] Boston Univ, Rush Alzheimers Dis Ctr, Med Ctr, Dept Neurol, Boston, MA USA

[7] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia

[8] Melbourne Hlth, Melbourne, Vic, Australia

[9] Harvard Univ, Brigham & Womens Hosp, Dept Radiol, Surg Planning Lab,MRI Div,Med Sch, Boston, MA 02215 USA

来源：

NEUROIMAGE | 2011年 / 55卷 / 04期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Diffusion tensor imaging; Schizophrenia; Stochastic tractography; Language network; Inferior frontal gyrus; Fractional anisotropy; WHITE-MATTER CHANGES; FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; 1ST-EPISODE SCHIZOPHRENIA; LONGITUDINAL FASCICULUS; LANGUAGE; ABNORMALITIES; PATHWAYS; WORD; HIPPOCAMPAL;

D O I：

10.1016/j.neuroimage.2011.01.047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Abnormalities within language-related anatomical structures have been associated with clinical symptoms and with language and memory deficits in schizophrenia. Recent studies suggest disruptions in functional connectivity within the Inferior Frontal Cyrus (IFG) network in schizophrenia. However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied. Material and methods: Diffusion and anatomical scans were obtained from 23 chronic schizophrenia patients and 23 matched controls. The IFG was automatically segmented, and its white matter connections extracted and measured with newly-developed stochastic tractography tools. Correlations between anatomical structures and measures of semantic processing were also performed. Results: White Matter connections between the IFG and posterior brain regions followed two distinct pathways: dorsal and ventral. Both demonstrated left lateralization, but ventral pathway abnormalities were only found in schizophrenia. IFG volumes also showed left lateralization and abnormalities in schizophrenia. Further, despite similar laterality and abnormality patterns. IFG volumes and white matter connectivity were not correlated with each other in either group. Interestingly, measures of semantic processing correlated with white matter connectivity in schizophrenia and with gray matter volumes in controls. Finally, hallucinations were best predicted by both gray matter and white matter measures together. Conclusions: Our results suggest abnormalities within the ventral IFG network in schizophrenia, with white matter abnormalities better predicting semantic deficits. The lack of a statistical relationship between coexisting gray and white matter deficits might suggest their different origin and the necessity for a multimodal approach in future schizophrenia studies. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1657 / 1664

页数：8

共 66 条

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