Angioarrestin: A unique angiopoietin-related protein with anti-angiogenic properties

被引：21

作者：

Dhanabal, M ^{[1
]}

Jeffers, M ^{[1
]}

LaRochelle, WJ ^{[1
]}

Lichenstein, HS ^{[1
]}

机构：

[1] CuraGen Corp, Dept Preclin Dev, Branford, CT 06405 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 333卷 / 02期

关键词：

VEGF; angiogenesis; angiopoietin; Tie; 1; 2; ARP; HFARP; CDT; 6; angioarrestin;

D O I：

10.1016/j.bbrc.2005.05.134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The process of angiogenesis plays a pivotal role in embryogenesis, wound healing, and tumorigenesis through the growth of new blood vessels from pre-existing vasculature. Among the angiogenic factors recently identified as specific for vascular endothelium are the angiopoietins. In depth characterization of the angiopoietins has allowed investigators to better understand the molecular basis of blood vessel formation and vascular endothelial cell function. In this review, we describe angiopoietins and related family members, with particular emphasis on a recently identified protein known as angioarrestin. Our investigations clearly demonstrate that angioarrestin is an anti-angiogenic molecule. The effects of angioarrestin on tumor cell progression and specific aspects of the angiogenic cascade in in vitro models are further discussed. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：308 / 315

页数：8

共 56 条

[11]

Dhanabal M, 2002, CANCER RES, V62, P3834

[12] ASSIGNMENT OF THE ENDOTHELIAL-SPECIFIC PROTEIN-RECEPTOR TYROSINE KINASE GENE (TEK) TO HUMAN-CHROMOSOME 9P21 [J].

DUMONT, DJ ;

ANDERSON, L ;

BREITMAN, ML ;

DUNCAN, AMV .

GENOMICS, 1994, 23 (02) :512-513

[13] DOMINANT-NEGATIVE AND TARGETED NULL MUTATIONS IN THE ENDOTHELIAL RECEPTOR TYROSINE KINASE, TEK, REVEAL A CRITICAL ROLE IN VASCULOGENESIS OF THE EMBRYO [J].

DUMONT, DJ ;

GRADWOHL, G ;

FONG, GH ;

PURI, MC ;

GERTSENSTEIN, M ;

AUERBACH, A ;

BREITMAN, ML .

GENES & DEVELOPMENT, 1994, 8 (16) :1897-1909

[14]

Etoh T, 2001, CANCER RES, V61, P2145

[15] The biology of vascular endothelial growth factor [J].

Ferrara, N ;

DavisSmyth, T .

ENDOCRINE REVIEWS, 1997, 18 (01) :4-25

[16]

FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182

[17]

Folkman J, 1974, Adv Cancer Res, V19, P331, DOI 10.1016/S0065-230X(08)60058-5

[18] Role of angiopoietins in reproductive tract angiogenesis [J].

Geva, E ;

Jaffe, RB .

OBSTETRICAL & GYNECOLOGICAL SURVEY, 2000, 55 (08) :511-519

[19]

Goede V, 1998, LAB INVEST, V78, P1385

[20] Tie-2 and angiopoietin-2 expression at the fetal-maternal interface: a receptor ligand model for vascular remodelling [J].

Goldman-Wohl, DS ;

Ariel, I ;

Greenfield, C ;

Lavy, Y ;

Yagel, S .

MOLECULAR HUMAN REPRODUCTION, 2000, 6 (01) :81-87

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