Synthesis and biological activity of some pyrazoline derivatives

Heterosubstituted pyrazoline derivatives were synthesized by reacting with (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones (1a-j) with isonicotinohydrazide in gl acetic acid ethanol followed by cyclocondensation to give 4-{[3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-4,5-dihydro-1H-pyrazol-1 -yl] carbonyl} pyridines (2a-j). Compounds (1a-j) on further reaction with 4-chlorobenzohydrazide in presence of gl acetic acid gave 1-(4-chlorobenzoyl)-3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-4,5-dihydro-1H-pyrazolines (3a-j). Their IR, H-1 NMR, Mass spectral data and elemental analysis were in accord with assigned structures. All the compounds were screened for their antimicrobial activity while compound (3a-j) were screened for their antitubercular activity.