VNS;
Treatment-resistant depression;
Dorsolateral prefrontal cortex;
SPECT;
TRANSCRANIAL MAGNETIC STIMULATION;
BRAIN-STIMULATION;
MAJOR DEPRESSION;
EFFICACY;
SAFETY;
METABOLISM;
GUIDELINES;
DISORDERS;
CIRCUITS;
EPILEPSY;
D O I:
10.1016/j.pscychresns.2010.11.004
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
The purpose of the present study was to assess the effects of vagus nerve stimulation (VNS) therapy on regional cerebral blood flow (rCBF) in depressed patients. Regional cerebral blood flow (rCBF) was assessed by [Tc-99m]-HMPAO-single photon emission computed tomography (SPECT) before and after 10 weeks of VNS in patients participating in an open, uncontrolled European multi-center study investigating efficacy and safety of VNS. Patients suffered from major depression, with a baseline score of >= 20 on the 24-item Hamilton Depression Rating Scale (HDRS) and had been unsuccessfully treated with at least two adequately prescribed antidepressant drugs. Data of 15 patients could be analyzed using SPM 2. After 10 weeks of VNS (20 Hz, 500 mu s pulse width, stimulation during 30 s every 5 min at the maximal comfortable level) rCBF was increased in the left dorsolateral/ventrolateral prefrontal cortex (Brodmann areas 46 and 47) and decreased in the right posterior cingulate area, the lingual gyrus and the left insula. Our findings are in line with earlier results which showed that VNS increases rCBF in the left dorsolateral prefrontal cortex. The modulation of the activity in this region could be associated with the antidepressant efficacy of VNS. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
机构:
Vet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Pardo, Jose V.
Sheikh, Sohail A.
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机构:
Vet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Sheikh, Sohail A.
Schwindt, Graeme C.
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Vet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Schwindt, Graeme C.
Lee, Joel T.
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机构:
Vet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Lee, Joel T.
Kuskowski, Michael A.
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机构:
Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Kuskowski, Michael A.
Surerus, Christa
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Vet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Surerus, Christa
Lewis, Scott M.
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机构:
Dept Neurol, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Lewis, Scott M.
Abuzzahab, Faruk S.
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机构:
Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Abuzzahab, Faruk S.
Adson, David E.
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Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
Adson, David E.
Rittberg, Barry R.
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机构:
Dept Psychiat, Minneapolis, MN USAVet Affairs Med Ctr, Cognit Neuroimaging Unit, Minneapolis, MN USA
机构:
Insubria Univ, Neurosurg Clin, Varese, ItalyUniv Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, Italy
Dario, Alessandro
Ciabatti, Mariateresa
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机构:
Univ Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, Italy
Ciabatti, Mariateresa
Camuri, Criulia
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机构:
Univ Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, Italy
Camuri, Criulia
Oldani, Lucio
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机构:
Univ Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, Italy
Oldani, Lucio
Balossi, Ilaria
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机构:
Univ Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, Italy
Balossi, Ilaria
Altamura, A. Carlo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, ItalyUniv Milan, Fdn IRCCS Ospedale Maggiore Policlin Mangiagalli, Via Francesco Sforza 35, I-20122 Milan, Italy