Cell Type-Specific Separation of Subicular Principal Neurons during Network Activities

被引:19
作者
Eller, Joanna [1 ]
Zarnadze, Shota [1 ]
Bauerle, Peter [1 ]
Dugladze, Tamar [1 ,2 ]
Gloveli, Tengis [1 ,3 ]
机构
[1] Charite, Inst Neurophysiol, Cellular & Network Physiol Grp, D-13353 Berlin, Germany
[2] Cluster Excellence NeuroCure, Berlin, Germany
[3] Bernstein Ctr Computat Neurosci Berlin, Berlin, Germany
关键词
ELECTROPHYSIOLOGICALLY-DEFINED CLASSES; TEMPORAL-LOBE EPILEPSY; RAT VENTRAL SUBICULUM; LIMBIC GAMMA RHYTHMS; IN-VITRO; PYRAMIDAL NEURONS; INTRINSIC-PROPERTIES; REGULAR-SPIKING; HIPPOCAMPUS; OSCILLATIONS;
D O I
10.1371/journal.pone.0123636
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The hippocampal output structure, the subiculum, expresses two major memory relevant network rhythms, sharp wave ripple and gamma frequency oscillations. To this date, it remains unclear how the two distinct types of subicular principal cells, intrinsically bursting and regular spiking neurons, participate in these two network rhythms. Using concomitant local field potential and intracellular recordings in an in vitro mouse model that allows the investigation of both network rhythms, we found a cell type-specific segregation of principal neurons into participating intrinsically bursting and non-participating regular spiking cells. However, if regular spiking cells were kept at a more depolarized level, they did participate in a specific manner, suggesting a potential bimodal working model dependent on the level of excitation. Furthermore, intrinsically bursting and regular spiking cells exhibited divergent intrinsic membrane and synaptic properties in the active network. Thus, our results suggest a cell-type-specific segregation of principal cells into two separate groups during network activities, supporting the idea of two parallel streams of information processing within the subiculum.
引用
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页数:18
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