Synthesis, Characterization and DNA-Binding of Two Cationic Peptides

被引：0
|
作者：
Liu, Jie [1 ]
Zhao, Xiao-yan [1 ]
Wang, Hong-hui [1 ]
Lu, Kui [2 ]
机构：
[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China
[2] Henan Inst Engn, Dept Mat & Chem Engn, Zhengzhou 451191, Henan, Peoples R China
来源：
ADVANCES IN BIOMEDICAL ENGINEERING | 2011年
基金：
美国国家科学基金会;
关键词：
Cationic peptide; Solid-phase synthesis; DNA-binding; UV spectroscopy; Fluorescence quenching spectroscopy; FLUORESCENCE; PROBE;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Two cationic peptides Cys-(Lys), and Cys-(Lys)(5)-Ala were synthesized by Fmoc Solid-phase Synthesis and characterized by ESI-MS. The interaction of Cys-(Lys)4 and Cys-(Lys)5-Ala with ct-DNA was investigated by Ultraviolet Visible aborption spectrometry and fluorescence spectroscopy. The results show that the DNA-binding modes is intercalative interaction and the cationic peptides might have strong anti-ancer activities.
引用
收藏
页码：173 / +
页数：2
相关论文
共 50 条
  • [31] Synthesis of ruthenium(II) complexes and characterization of their cytotoxicity in vitro, apoptosis, DNA-binding and antioxidant activity
    Liu, Yun-Jun
    Zeng, Cheng-Hui
    Liang, Zhen-Hua
    Yao, Jun-Hua
    Huang, Hong-Liang
    Li, Zheng-Zheng
    Wu, Fu-Hai
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (07) : 3087 - 3095
  • [32] Review: Synthesis, characterization, and DNA-binding properties of Ru(II) molecular "light switch" complexes
    Devi, C. Shobha
    Satyanarayana, S.
    JOURNAL OF COORDINATION CHEMISTRY, 2012, 65 (03) : 474 - 486
  • [33] Synthesis, Characterization, and DNA-Binding and -Cleavage Properties of Dinuclear CuII-Salophen/Salen Complexes
    Reddy, Pulimamidi Rabindra
    Shilpa, Addla
    CHEMISTRY & BIODIVERSITY, 2011, 8 (07) : 1245 - 1265
  • [34] Synthesis, Characterization, and DNA-Binding Studies of Mononuclear Copper(II)-Phenanthroline-Tyrosine Complex
    Reddy, Pulimamidi R.
    Manjula, Pallerla
    CHEMISTRY & BIODIVERSITY, 2009, 6 (01) : 71 - 78
  • [35] Synthesis, DNA-binding properties and cytotoxicity evaluation of two copper(II) complexes based on curcumin
    Xue, Xuan
    Wang, Jiafeng
    Si, Guifu
    Wang, Chengming
    Zhou, Shuangsheng
    TRANSITION METAL CHEMISTRY, 2016, 41 (03) : 331 - 337
  • [36] Synthesis, Characterization, and DNA-Binding of Chiral Complexes Δ- and Λ-[Ru(bpy)2(pyip)]2+
    Shi, Shuo
    Yao, Tian-Ming
    Geng, Xiao-Ting
    Jiang, Ling-Feng
    Liu, Jie
    Yang, Qing-Yuan
    Ji, Liang-Nian
    CHIRALITY, 2009, 21 (02) : 276 - 283
  • [37] Synthesis, characterization, and DNA binding of two copper (II) complexes as DNA fluorescent probes
    Duan, Ran-Ran
    Wang, Lu
    Huo, Wei-Qiang
    Chen, Shi
    Zhou, Xiao-Hua
    JOURNAL OF COORDINATION CHEMISTRY, 2014, 67 (16) : 2765 - 2782
  • [38] Sequence-based prediction of DNA-binding sites on DNA-binding proteins
    Gou, Z.
    Hwang, S.
    Kuznetsov, B., I
    PROCEEDINGS OF THE FIFTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE, VOL 1, 2006, : 268 - +
  • [39] Cytotoxic Activity and DNA-Binding Investigations of Two Benzoxanthone Derivatives
    Wang, Hui-Fang
    Shen, Rui
    Jia, Lei
    Wu, Jin-Cai
    Tang, Ning
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (08) : 808 - 813
  • [40] DNA-Binding Anticancer Drugs: One Target, Two Actions
    Baguley, Bruce C.
    Drummond, Catherine J.
    Chen, Ying Yi
    Finlay, Graeme J.
    MOLECULES, 2021, 26 (03):
12345