Synthesis, Characterization and DNA-Binding of Two Cationic Peptides

被引：0
|
作者：
Liu, Jie [1 ]
Zhao, Xiao-yan [1 ]
Wang, Hong-hui [1 ]
Lu, Kui [2 ]
机构：
[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China
[2] Henan Inst Engn, Dept Mat & Chem Engn, Zhengzhou 451191, Henan, Peoples R China
来源：
ADVANCES IN BIOMEDICAL ENGINEERING | 2011年
基金：
美国国家科学基金会;
关键词：
Cationic peptide; Solid-phase synthesis; DNA-binding; UV spectroscopy; Fluorescence quenching spectroscopy; FLUORESCENCE; PROBE;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Two cationic peptides Cys-(Lys), and Cys-(Lys)(5)-Ala were synthesized by Fmoc Solid-phase Synthesis and characterized by ESI-MS. The interaction of Cys-(Lys)4 and Cys-(Lys)5-Ala with ct-DNA was investigated by Ultraviolet Visible aborption spectrometry and fluorescence spectroscopy. The results show that the DNA-binding modes is intercalative interaction and the cationic peptides might have strong anti-ancer activities.
引用
收藏
页码：173 / +
页数：2
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