Synthesis, Characterization and DNA-Binding of Two Cationic Peptides

被引：0

作者：

Liu, Jie ^{[1
]}

Zhao, Xiao-yan ^{[1
]}

Wang, Hong-hui ^{[1
]}

Lu, Kui ^{[2
]}

机构：

[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China

[2] Henan Inst Engn, Dept Mat & Chem Engn, Zhengzhou 451191, Henan, Peoples R China

来源：

ADVANCES IN BIOMEDICAL ENGINEERING | 2011年

基金：

美国国家科学基金会;

关键词：

Cationic peptide; Solid-phase synthesis; DNA-binding; UV spectroscopy; Fluorescence quenching spectroscopy; FLUORESCENCE; PROBE;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Two cationic peptides Cys-(Lys), and Cys-(Lys)(5)-Ala were synthesized by Fmoc Solid-phase Synthesis and characterized by ESI-MS. The interaction of Cys-(Lys)4 and Cys-(Lys)5-Ala with ct-DNA was investigated by Ultraviolet Visible aborption spectrometry and fluorescence spectroscopy. The results show that the DNA-binding modes is intercalative interaction and the cationic peptides might have strong anti-ancer activities.

引用

页码：173 / +

页数：2

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