Drug-lipid interactions in the model membrane, DPPC-water: A DSC and proton NMR study.

被引：2

作者：

Deniz, KU ^{[1
]}

Panicker, L ^{[1
]}

Parvathanathan, PS ^{[1
]}

Datta, G ^{[1
]}

Vivekanandan, S ^{[1
]}

Ramanathan, KV ^{[1
]}

Khetrapal, CL ^{[1
]}

机构：

[1] INDIAN INST SCI,SOPHISTICATED INSTRUMENTS FACIL,BANGALORE 560012,KARNATAKA,INDIA

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 1996年 / 288卷

关键词：

D O I：

10.1080/10587259608034600

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The interactions of the keratolytic drug Salicylic Acid (SA) and the antifungal drugs Methyl Paraben (MPB) and Propyl Paraben (PPB) with the model membrane, DPPC-Water, have been studied using DSC and H-1 NMR. The results show that these drug molecules are situated near the membrane interface with their polar group(s) interacting with the vicinal water, while the aromatic regions and the methyl and propyl groups of MPB and PPB interact with the neighbouring hydrophobic regions of the DPPC molecule. The strength of interaction of the aromatic group is in the order PPB > MPB > SA.

引用

页码：237 / 247

页数：11

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