Combined analysis of MIB-1 and thyroid transcription factor-1 predicts survival in non-small cell lung carcinomas

被引：30
作者：
Puglisi, F
Aprile, C
Bruckbauer, M
Barbone, F
Damante, G
Guerra, S
Beltrami, CA
Di Loreto, C
机构：
[1] Univ Udine, Dept Clin Oncol, I-33100 Udine, Italy
[2] Univ Udine, Dept Anat Pathol, I-33100 Udine, Italy
[3] Univ Udine, Dept Hyg, I-33100 Udine, Italy
[4] Univ Udine, Dept Genet, I-33100 Udine, Italy
来源：
CANCER LETTERS | 2001年 / 162卷 / 01期
关键词：
non-small cell lung carcinomas; prognosis; thyroid transcription factor-1; MIB-1; survival analysis; combined analysis;
D O I：
10.1016/S0304-3835(00)00625-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prognostic value of combined immunohistochemical analysis for the thyroid transcription factor-1 (TTF-1) and the proliferation marker MIB-1 was assessed in a consecutive series of non-small cell lung carcinomas (NSCLC). Tumor immunoreactivity for TTF-1 and MIB-1 was classified in three groups (-,+,+ +) and in two groups (-,+), respectively. Comparison across groups for TTF-1 reactivity showed significantly different survival curves (P = 0.04). In particular, the best prognosis was associated with a TTF-1 negative pattern, whereas the TTF-1 '++' cases showed the worst prognosis. A trend towards better prognosis was observed for MIB-1 negative cases (P = 0.09). Multivariate analysis confirmed independent prognostic significance of TTF-1 (P = 0.002), MIB-1 (P = 0.01) and pStage (P = 0.04). Accordingly, analysing TTF-1 and MIB-1 together, a better prediction of survival was obtained (P = 0.02), with the poorest prognosis for the 'TTF-1++/MIB-1+' cases. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：97 / 103
页数：7
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