RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications

被引：58

作者：

Ireton, Renee C. ^{[1
]}

Gale, Michael, Jr. ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Sch Med, Seattle, WA 98195 USA

来源：

VIRUSES-BASEL | 2011年 / 3卷 / 06期

关键词：

RIG-I; inflammation; adjuvant; INDUCIBLE GENE-I; DENDRITIC CELLS; 5'-TRIPHOSPHATE RNA; INNATE; RECOGNITION; IDENTIFICATION; RESPONSES; SENSOR; MDA5; REQUIREMENT;

D O I：

10.3390/v3060906

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection.

引用

页码：906 / 919

页数：14

共 60 条

[11] Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays
Der, SD
Zhou, AM
Williams, BRG
Silverman, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) : 15623 - 15628
[12] Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p
Dong, BH
Niwa, M
Walter, P
Silverman, RH
[J]. RNA, 2001, 7 (03) : 361 - 373
[13] The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
Eisenaecher, Katharina
Steinberg, Christian
Reindl, Wolfgang
Krug, Anne
[J]. IMMUNOBIOLOGY, 2007, 212 (9-10) : 701 - 714
[14] Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
Foy, E
Li, K
Sumpter, R
Loo, YM
Johnson, CL
Wang, CF
Fish, PM
Yoneyama, M
Fujita, T
Lemon, SM
Gale, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) : 2986 - 2991
[15] Selective Downregulation of Retinoic Acid-Inducible Gene I Within the Intestinal Epithelial Compartment in Crohn's Disease
Funke, Benjamin
Lasitschka, Felix
Roth, Wilfried
Penzel, Roland
Meuer, Stefan
Saile, Maria
Gretz, Norbert
Sido, Bernd
Schirmacher, Peter
Autschbach, Frank
[J]. INFLAMMATORY BOWEL DISEASES, 2011, 17 (09) : 1943 - 1954
[16] TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Gack, Michaela U.
Shin, Young C.
Joo, Chul-Hyun
Urano, Tomohiko
Liang, Chengyu
Sun, Lijun
Takeuchi, Osamu
Akira, Shizuo
Chen, Zhijian
Inoue, Satoshi
Jung, Jae U.
[J]. NATURE, 2007, 446 (7138) : 916 - U2
[17] Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells
Hirata, Yoshihiro
Broquet, Alexis H.
Menchen, Luis
Kagnoff, Martin F.
[J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (08) : 5425 - 5432
[18] Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells
Hong, Bangxing
Song, Xiao-Tong
Rollins, Lisa
Berry, Lindsey
Huang, Xue F.
Chen, Si-Yi
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (02) : 739 - 751
[19] Intracellular Innate Immune Cascades and Interferon Defenses That Control Hepatitis C Virus
Horner, Stacy M.
Gale, Michael, Jr.
[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2009, 29 (09) : 489 - 498
[20] 5′-triphosphate RNA is the ligand for RIG-I
Hornung, Veit
Ellegast, Jana
Kim, Sarah
Brzozka, Krzysztof
Jung, Andreas
Kato, Hiroki
Poeck, Hendrik
Akira, Shizuo
Conzelmann, Karl-Klaus
Schlee, Martin
Endres, Stefan
Hartmann, Gunther
[J]. SCIENCE, 2006, 314 (5801) : 994 - 997

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