Effects of antioxidants streptozotocin-induced clastogenesis in mammalian and insect cells

被引：13

作者：

Bolzán, AD ^{[1
]}

Bianchi, NO ^{[1
]}

Bianchi, MS ^{[1
]}

机构：

[1] IMBICE, RA-1900 La Plata, Argentina

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1998年 / 418卷 / 01期

关键词：

streptozotocin; superoxide dismutase; catalase; mannitol; chromosomal aberration;

D O I：

10.1016/S1383-5718(98)00107-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and the hydroxyl radical scavenger mannitol (MAN) on the clastogenesis induced by STZ in Chinese hamster ovary (CHO) and mosquito cells were investigated. The addition of liposome-entrapped SOD, CAT and MAN to both cell lines caused a significant decrease in the yield of STZ-induced chromosome aberrations (p < 0.05). However, the inhibitory effect was more evident in CHO (40.6-67.5%) than in mosquito (15.2-53.6%) cells. These findings indicate that the chromosome damage induced by STZ can be partially inhibited through the incorporation of antioxidant compounds into the cells and suggest that free radicals are involved in the clastogenesis by STZ. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：35 / 42

页数：8

共 28 条

[1] N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets [J].

Bedoya, FJ ;

Solano, F ;

Lucas, M .

EXPERIENTIA, 1996, 52 (04) :344-347

[2]

BENNETT RA, 1981, CANCER RES, V41, P2786

[3]

BHUYAN BK, 1969, IN VITRO, V4, P154

[4] STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE-HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS [J].

CAPUCCI, MS ;

HOFFMANN, ME ;

NATARAJAN, AT .

MUTATION RESEARCH LETTERS, 1995, 347 (02) :79-85

[5] STREPTOZOTOCIN-INDUCED TOXICITY IN CHO-9 AND V79 CELLS [J].

CAPUCCI, MS ;

HOFFMANN, ME ;

DEGROOT, A ;

NATARAJAN, AT .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1995, 26 (01) :72-78

[6] STREPTOZOTOCIN-INDUCED CHROMOSOMAL-ABERRATIONS, SCES AND MUTATIONS IN CHO-9 PARENTAL CELLS AND IN EM-C-11 MUTANT-CELL LINE [J].

CAPUCCI, MS ;

HOFFMANN, ME ;

ZDZIENICKA, MZ ;

NATARAJAN, AT .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1995, 326 (02) :227-234

[7]

DORR RT, 1980, STREPTOZOTOCIN CANC, P632

[8]

Fisher R.A., 1957, STAT TABLES BIOL AGR, P61

[9]

GANDY SE, 1982, CLIN RES, V30, pA392

[10]

GANDY SE, 1983, DIABETOLOGIA, V24, P437

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