In vitro activity of Fluoroquinolones against Mycobacterium tuberculosis

被引：59
作者：
Sulochana, S [1 ]
Rahman, F [1 ]
Paramasivan, CN [1 ]
机构：
[1] ICMR, TB Res Ctr, Madras 600031, Tamil Nadu, India
来源：
JOURNAL OF CHEMOTHERAPY | 2005年 / 17卷 / 02期
关键词：
Mycobacterium tuberculosis; fluoroquinolones; lomefloxacin; ofloxacin; ciprofloxacin; sparfloxacin; moxifloxacin; gatifloxacin;
D O I：
10.1179/joc.2005.17.2.169
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The in vitro activity of fluoroquinolones, including lomefloxacin, ofloxacin, ciprofloxacin, sparfloxacin, moxifloxacin and gatifloxacin, was evaluated against 55 clinical isolates of Mycobacterium tuberculosis by absolute concentration method on Lowenstein-Jensen (L-J) and Middlebrook's 7H11 media. Both ofloxacin susceptible and ofloxacin resistant strains of M. tuberculosis isolates were tested. The in vitro activities of these fluoroquinolones on the M. tuberculosis isolates were in the order: lomefloxacin < ciprofloxacin < ofloxacin < sparfloxacin < moxifloxacin=gatifloxacin. Gatifloxacin and moxifloxacin showed low minimal inhibitory concentrations (MIC) for both ofloxacin resistant and ofloxacin susceptible strains even though some cross resistances were observed.
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页码：169 / 173
页数：5
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