Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells

被引：33

作者：

Florido, Javier ^{[1
,2
]}

Rodriguez-Santana, Cesar ^{[1
,2
]}

Martinez-Ruiz, Laura ^{[1
,2
]}

Lopez-Rodriguez, Alba ^{[1
,2
]}

Acuna-Castroviejo, Dario ^{[1
,2
,3
]}

Rusanova, Iryna ^{[1
,3
,4
]}

Escames, Germaine ^{[1
,2
,3
]}

机构：

[1] Univ Granada, Biomed Res Ctr, Hlth Sci Technol Pk, Granada 18016, Spain

[2] Univ Granada, Fac Med, Dept Physiol, Granada 18016, Spain

[3] San Cecilio Univ Hosp, Ctr Invest Biomed Red Fragilidad & Envejecimiento, Ibs Granada, Granada 18016, Spain

[4] Univ Granada, Fac Sci, Dept Biochem & Mol Biol, Granada 18019, Spain

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 08期

关键词：

melatonin; reactive oxygen species; apoptosis; mitochondria; cancer; PROMOTES APOPTOSIS; ANTITUMOR-ACTIVITY; INHIBITION; ANTIOXIDANT; MITOCHONDRIA; EXPRESSION; PHENOTYPE; MIGRATION; DEFENSE; STRESS;

D O I：

10.3390/antiox11081621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death. Melatonin is of particular importance in the development of innovative cancer treatments due to its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic clinical applications.

引用

页数：13

共 95 条

[1] The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer [J].