FRAX Update

被引：82
作者：
Kanis, John A. [1 ,2 ]
Harvey, Nicholas C. [3 ]
Johansson, Helena [1 ,4 ]
Oden, Anders [1 ]
Leslie, William D. [5 ]
McCloskey, Eugene V. [1 ]
机构：
[1] Univ Sheffield, Sch Med, Ctr Metab Bone Dis, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[2] Australian Catholic Univ, Inst Hlth & Ageing, Melbourne, Vic, Australia
[3] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England
[4] Univ Gothenburg, Sahlgrenska Acad, CBAR, Gothenburg, Sweden
[5] Univ Manitoba, Dept Internal Med, Winnipeg, MB, Canada
来源：
JOURNAL OF CLINICAL DENSITOMETRY | 2017年 / 20卷 / 03期
基金：
英国医学研究理事会;
关键词：
Clinical risk factors; fracture probability; FRAX; intervention thresholds; risk assessment; FRACTURE RISK-ASSESSMENT; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; TRABECULAR BONE SCORE; POSTMENOPAUSAL WOMEN; INTERVENTION THRESHOLDS; CLINICAL FRACTURES; MINERAL DENSITY; HIP-FRACTURES; MANAGEMENT; PROBABILITY;
D O I：
10.1016/j.jocd.2017.06.022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The fracture risk assessment tool, FRAX, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, models are now available for 63 countries, covering 79% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. However, the application of FRAX in guidelines has been heterogeneous with the adoption of several different approaches to setting intervention thresholds. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future. A more unified approach to setting intervention thresholds with FRAX is a research priority.
引用
收藏
页码：360 / 367
页数：8
相关论文
共 69 条
  • [41] The cost-effectiveness of alendronate in the management of osteoporosis
    Kanis, John A.
    Adams, Judith
    Borgstrom, Fred
    Cooper, Cyrus
    Jonsson, Bengt
    Preedy, Danielle
    Selby, Peter
    Compston, Juliet
    [J]. BONE, 2008, 42 (01) : 4 - 15
  • [42] A systematic review of intervention thresholds based on FRAX A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation
    Kanis, John A.
    Harvey, Nicholas C.
    Cooper, Cyrus
    Johansson, Helena
    Oden, Anders
    McCloskey, Eugene V.
    [J]. ARCHIVES OF OSTEOPOROSIS, 2016, 11 (01)
  • [43] Intervention Thresholds and the Diagnosis of Osteoporosis
    Kanis, John A.
    McCloskey, Eugene V.
    Harvey, Nicholas C.
    Johansson, Helena
    Leslie, William D.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2015, 30 (10) : 1747 - 1753
  • [44] FRAXA® with and without Bone Mineral Density
    Kanis, John A.
    McCloskey, Eugene
    Johansson, Helena
    Oden, Anders
    Leslie, William D.
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2012, 90 (01) : 1 - 13
  • [45] A meta-analysis of the efficacy of raloxifene on all clinical and vertebral fractures and its dependency on FRA®
    Kanis, John A.
    Johansson, Helena
    Oden, Anders
    McCloskey, Eugene V.
    [J]. BONE, 2010, 47 (04) : 729 - 735
  • [46] Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX®
    Kanis, John A.
    Johansson, Helena
    Cden, Anders
    McCloskey, Eugene V.
    [J]. BONE, 2009, 44 (06) : 1049 - 1054
  • [47] An evaluation of the Fracture Risk Assessment Tool (FRAX®) as an indicator of treatment efficacy: the effects of bazedoxifene and raloxifene on vertebral, nonvertebral, and all clinical fractures as a function of baseline fracture risk assessed by FRAX®
    Kaufman, J. -M.
    Palacios, S.
    Silverman, S.
    Sutradhar, S.
    Chines, A.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2013, 24 (10) : 2561 - 2569
  • [48] A simple tool to identify Asian women at increased risk of osteoporosis
    Koh, LKH
    Ben Sedrine, W
    Torralba, TP
    Kung, A
    Fujiwara, S
    Chan, SP
    Huang, QR
    Rajatanavin, R
    Tsai, KS
    Park, HM
    Reginster, JY
    [J]. OSTEOPOROSIS INTERNATIONAL, 2001, 12 (08) : 699 - 705
  • [49] A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis
    Lekamwasam, S.
    Adachi, J. D.
    Agnusdei, D.
    Bilezikian, J.
    Boonen, S.
    Borgstrom, F.
    Cooper, C.
    Diez Perez, A.
    Eastell, R.
    Hofbauer, L. C.
    Kanis, J. A.
    Langdahl, B. L.
    Lesnyak, O.
    Lorenc, R.
    McCloskey, E.
    Messina, O. D.
    Napoli, N.
    Obermayer-Pietsch, B.
    Ralston, S. H.
    Sambrook, P. N.
    Silverman, S.
    Sosa, M.
    Stepan, J.
    Suppan, G.
    Wahl, D. A.
    Compston, J. E.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2012, 23 (09) : 2257 - 2276
  • [50] Lumbar spine texture enhances 10-year fracture probability assessment
    Leslie, W. D.
    Johansson, H.
    Kanis, J. A.
    Lamy, O.
    Oden, A.
    McCloskey, E. V.
    Hans, D.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2014, 25 (09) : 2271 - 2277
1234567