FRAX Update

被引：82

作者：

Kanis, John A. ^{[1
,2
]}

Harvey, Nicholas C. ^{[3
]}

Johansson, Helena ^{[1
,4
]}

Oden, Anders ^{[1
]}

Leslie, William D. ^{[5
]}

McCloskey, Eugene V. ^{[1
]}

机构：

[1] Univ Sheffield, Sch Med, Ctr Metab Bone Dis, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England

[2] Australian Catholic Univ, Inst Hlth & Ageing, Melbourne, Vic, Australia

[3] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[4] Univ Gothenburg, Sahlgrenska Acad, CBAR, Gothenburg, Sweden

[5] Univ Manitoba, Dept Internal Med, Winnipeg, MB, Canada

来源：

JOURNAL OF CLINICAL DENSITOMETRY | 2017年 / 20卷 / 03期

基金：

英国医学研究理事会;

关键词：

Clinical risk factors; fracture probability; FRAX; intervention thresholds; risk assessment; FRACTURE RISK-ASSESSMENT; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; TRABECULAR BONE SCORE; POSTMENOPAUSAL WOMEN; INTERVENTION THRESHOLDS; CLINICAL FRACTURES; MINERAL DENSITY; HIP-FRACTURES; MANAGEMENT; PROBABILITY;

D O I：

10.1016/j.jocd.2017.06.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The fracture risk assessment tool, FRAX, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, models are now available for 63 countries, covering 79% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. However, the application of FRAX in guidelines has been heterogeneous with the adoption of several different approaches to setting intervention thresholds. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future. A more unified approach to setting intervention thresholds with FRAX is a research priority.

引用

页码：360 / 367

页数：8

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