Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model

被引：20

作者：

Zhang, Linlin ^{[1
,2
]}

Liu, Yanzhong ^{[1
]}

Wang, Xin ^{[1
]}

Wang, Dan ^{[1
]}

Wu, Hao ^{[2
]}

Chen, Haichun ^{[1
]}

Chen, Jiaxin ^{[1
]}

Liu, Yiping ^{[1
]}

机构：

[1] Fujian Normal Univ, Prov Univ Key Lab Sport & Hlth Sci, Sch Phys Educ & Sport Sci, Fuzhou 350007, Peoples R China

[2] Capital Univ Phys Educ & Sports, Comprehens Key Lab Sports Abil Evaluat & Res Gen, Beijing Key Lab Sports Funct Assessment & Tech An, Beijing 100191, Peoples R China

来源：

PHYSIOLOGY & BEHAVIOR | 2022年 / 251卷

关键词：

Treadmill exercise; AD; Recognition memory; TREM2; pathway; OXIDATIVE STRESS; TAU PATHOLOGY; BETA; NEUROPROTECTION;

D O I：

10.1016/j.physbeh.2022.113820

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Alzheimer's disease-related cognition impairment is correlated with increased neuroinflammation. Studies show that physical exercises improve cognitive function and regulate neuroinflammation. However, no sufficient studies have been performed to directly observe the mechanism of exercise-related effects on microglia and neuroinflammation, in association with memory function under Alzheimer's disease. This study aims to explore the relationship of TREM2, microglia activation and neuroinflammation in the development of Alzheimer's disease, followed by investigating why physical exercises improve cognition in the Alzheimer's disease model by means of the adeno-associated virus (AAV) injection. We found that: 1) Recognition memory impairment in A beta-induced Alzheimer's disease model was associated with the reduction in TREM2 which induced microglial activation and neuroinflammation; 2) Exercise activated the TREM2 pathway, which was necessary for inhibiting microglial activation and neuroinflammation, leading to improved recognition memory in the Alzheimer's disease model. Together, the improvement of AD-associated recognition memory by exercises is associated with up-regulation of the TREM2 pathway which promotes the phenotypic conversion of microglia and decreases the level of neuroinflammation.

引用

页数：8

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