Reinforcing effects of methamphetamine in an animal model of Attention-Deficit/Hyperactivity Disorder-the Spontaneously Hypertensive Rat

被引:10
|
作者
dela Pena, Ike [1 ]
Ahn, Hyung Seok [1 ]
Choi, Ji Young [1 ]
Shin, Chan Young [2 ]
Ryu, Jong Hoon [3 ]
Cheong, Jae Hoon [1 ]
机构
[1] Sahmyook Univ, Uimyung Res Inst Neurosci, Seoul 139742, South Korea
[2] Konkuk Univ, Ctr Geriatr Neurosci Res, Inst Biomed Sci & Technol, Seoul 143701, South Korea
[3] Kyung Hee Univ, Dept Oriental Pharmaceut Sci, Seoul 130701, South Korea
来源
BEHAVIORAL AND BRAIN FUNCTIONS | 2010年 / 6卷
关键词
DEFICIT HYPERACTIVITY DISORDER; CONDITIONED PLACE PREFERENCE; SUBSTANCE DEPENDENCE; LOCOMOTOR; ADHD; METHYLPHENIDATE; COMORBIDITY; PREVALENCE; DRUG; NEUROCIRCUITRY;
D O I
10.1186/1744-9081-6-72
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Substrains of the Spontaneously Hypertensive rat (SHR), a putative animal model of Attention-Deficit/Hyperactivity Disorder (ADHD), have demonstrated increased sensitivity to many drugs of abuse, including psychostimulants. Therefore, it was suggested that studies in SHR may help elucidate ADHD and comorbidity with substance use disorder (SUD). However, the drug intake profile of the SHR in the most relevant animal model of drug addiction, the self-administration (SA) test, and its response on the conditioned place preference (CPP) paradigm are not yet determined. In the present study, we employed SA and CPP tests to investigate the reinforcing effects of the psychostimulant methamphetamine in an SHR substrain obtained from Charles River, Japan (SHR/NCrlCrlj). Concurrent tests were also performed in Wistar rats, the strain representing "normal" heterogeneous population. To address if the presence of ADHD behaviors further increases sensitivity to the rewarding effect of methamphetamine during adolescence, a critical period for the onset of drug abuse, CPP tests were especially conducted in adolescent Wistar and SHR/NCrlCrlj. We found that the SHR/NCrlCrlj also acquired methamphetamine SA and CPP, indicating reinforcing effects of methamphetamine in this ADHD animal model. However, we did not observe increased responsiveness of the SHR/NCrlCrlj to methamphetamine in both SA and CPP assays. This indicates that the reinforcing effects of methamphetamine may be similar in strains and that the SHR/NCrlCrlj may not adequately model ADHD and increased sensitivity to methamphetamine.
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页数:5
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