Recognition in molecularly imprinted polymer alpha(2)-adrenoreceptor mimics

被引：27

作者：

Berglund, J

Nicholls, IA

Lindbladh, C

Mosbach, K

机构：

[1] LUND UNIV,DEPT PURE & APPL BIOCHEM,S-22100 LUND,SWEDEN

[2] UNIV KALMAR,DEPT NAT SCI,S-39129 KALMAR,SWEDEN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 18期

关键词：

D O I：

10.1016/0960-894X(96)00406-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Molecularly imprinted polymers (MIPs) selective for the alpha(2)-adrenoreceptor antagonist yohimbine (1) have been prepared and studied as alpha(2)-adrenoreceptor mimics. Marked ligand stereoselectivity was demonstrated in radioligand binding and HPLC studies upon comparison to blank and corynanthine (2) MIPs. K-D values in the nanomolar range have been shown for anti-1 MIP prepared in chloroform solutions upon rebinding in organic media. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：2237 / 2242

页数：6

共 22 条

[1]

ANDERSSON LI, 1995, ACS SYM SER, V586, P89

[2] MIMICS OF THE BINDING-SITES OF OPIOID RECEPTORS OBTAINED BY MOLECULAR IMPRINTING OF ENKEPHALIN AND MORPHINE [J].