Association of the adiponectin rs266729 C > G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort

被引：12
作者：
Prior, Sarah L. [1 ]
Jones, Danielle A. [1 ]
Gill, Geoffrey V. [2 ]
Bain, Steve C. [1 ]
Stephens, Jeffrey W. [1 ]
机构：
[1] Swansea Univ, Inst Life Sci, Diabet Res Grp, Swansea SA2 8PP, W Glam, Wales
[2] Univ Liverpool, Dept Endocrinol & Diabet, Ctr Clin Sci, Univ Hosp Aintree, Liverpool L9 1AE, Merseyside, England
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2011年 / 91卷 / 03期
关键词：
Adiponectin; Gene variant; Coronary heart disease; Obesity; Type; 1; diabetes; SUSCEPTIBILITY LOCUS; SERUM ADIPONECTIN; NEPHROPATHY; METAANALYSIS; LINKAGE;
D O I：
10.1016/j.diabres.2010.12.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The C-allele of rs266729 is associated with CHD, while the G-allele of rs17300539 is associated with metabolic traits. We examined these in type 1 diabetes. For rs266729, the C-allele was associated with 8-fold increase in CHD. For rs17300539, the G-allele was associated with increases in triglycerides and waist circumference. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：E71 / E74
页数：4
相关论文
共 20 条
[1]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[2]   Characteristics of Type 1 diabetes of over 50 years duration (the Golden Years Cohort) [J].
Bain, SC ;
Gill, GV ;
Dyer, PH ;
Jones, AF ;
Murphy, M ;
Jones, KE ;
Smyth, C ;
Barnett, AH .
DIABETIC MEDICINE, 2003, 20 (10) :808-811
[3]   Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q [J].
Chiodini, BD ;
Lewis, CM .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (10) :1863-1868
[4]   The-11391 G/A Polymorphism of the Adiponectin Gene Promoter is Associated with Metabolic Syndrome Traits and the Outcome of an Energy-restricted Diet in Obese Subjects [J].
Coyenechea, E. ;
Collins, L. J. ;
Parra, D. ;
Abete, I. ;
Crujeiras, A. B. ;
O'Dell, S. D. ;
Martinez, J. A. .
HORMONE AND METABOLIC RESEARCH, 2009, 41 (01) :55-61
[5]   A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27 [J].
Francke, S ;
Manraj, M ;
Lacquemant, C ;
Lecoeur, C ;
Leprêtre, F ;
Passa, P ;
Hebe, A ;
Corset, L ;
Yan, SLK ;
Lahmidi, S ;
Jankee, S ;
Gunness, TK ;
Ramjuttun, US ;
Balgobin, V ;
Dina, C ;
Froguel, P .
HUMAN MOLECULAR GENETICS, 2001, 10 (24) :2751-2765
[6]   Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications [J].
Frystyk, J ;
Tarnow, L ;
Hansen, TK ;
Parving, HH ;
Flyvbjerg, A .
DIABETOLOGIA, 2005, 48 (09) :1911-1918
[7]   Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects [J].
Gable, D. R. ;
Matin, J. ;
Whittall, R. ;
Cakmak, H. ;
Li, Ka Wah ;
Cooper, J. ;
Miller, G. J. ;
Humphries, S. E. .
ANNALS OF HUMAN GENETICS, 2007, 71 :453-466
[8]   Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: A meta-analysis [J].
Gong, M. ;
Long, Jian ;
Liu, Q. ;
Deng, H. C. .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 325 (1-2) :78-83
[9]  
Gu HF, 2009, BIOMARK INSIGHTS, V4, P123
[10]   Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: A nested case-control study [J].
Hegener, Hillary H. ;
Lee, I-Min ;
Cook, Nancy R. ;
Ridker, Paul M. ;
Zee, Robert Y. L. .
CLINICAL CHEMISTRY, 2006, 52 (11) :2021-2027
12