Therapeutic potential of LIF in multiple sclerosis

被引：35

作者：

Slaets, Helena ^{[1
,2
]}

Hendriks, Jerome J. A. ^{[1
,2
]}

Stinissen, Piet ^{[1
,2
]}

Kilpatrick, Trevor J. ^{[3
,4
]}

Hellings, Niels ^{[1
,2
]}

机构：

[1] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium

[2] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium

[3] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia

[4] Univ Melbourne, Howard Florey Inst, Melbourne, Vic 3010, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2010年 / 16卷 / 11期

关键词：

LEUKEMIA INHIBITORY FACTOR; LIMITS AUTOIMMUNE DEMYELINATION; CILIARY NEUROTROPHIC FACTOR; SPINAL-CORD-INJURY; NEURODEGENERATIVE CONDITIONS; SYNOVIAL-FLUID; MOUSE MODEL; STEM-CELLS; PHASE-II; CYTOKINE;

D O I：

10.1016/j.molmed.2010.08.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Therapies for multiple sclerosis (MS) reduce the relapse rate but are unable to stop neurological decline. Here, we evaluate the potential of leukemia inhibitory factor (LIF) as a novel therapeutic in diseases with a neurodegenerative and inflammatory component, such as MS. LIF, which can be a proinflammatory cytokine, can also modulate the immune response in a beneficial way. Recent evidence demonstrates a crucial role of LIF in neuroprotection and axonal regeneration as well as the prevention of demyelination. Finally, LIF is an important survival factor for stem cells and neuronal precursors. Therefore, we propose that LIF is a potential therapeutic candidate for MS.

引用

页码：493 / 500

页数：8

共 85 条

[1] Influence of LIF and BMP-2 on differentiation and development of glial cells in primary cultures of embryonic rat cerebral hemisphere [J].

Adachi, T ;

Takanaga, H ;

Kunimoto, M ;

Asou, H .

JOURNAL OF NEUROSCIENCE RESEARCH, 2005, 79 (05) :608-615

[2]

ALVAREZ JI, BIOCH BIOPH IN PRESS

[3]

[Anonymous], 1999, Neurology, V53, P457

[4] Astrocyte Differentiation of Neural Precursor Cells is Enhanced by Retinoic Acid Through a Change in Epigenetic Modification [J].

Asano, Hirotsugu ;

Aonuma, Makoto ;

Sanosaka, Tsukasa ;

Kohyama, Jun ;

Namihira, Masakazu ;

Nakashima, Kinichi .

STEM CELLS, 2009, 27 (11) :2744-2752

[5] Induction of endogenous neural precursors in mouse models of spinal cord injury and disease [J].

Azari, MF ;

Profyris, C ;

Zang, DW ;

Petratos, S ;

Cheema, SS .

EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 (08) :638-648

[6] Leukemia inhibitory factor arrests oligodendrocyte death and demyelination in spinal cord injury [J].

Azari, Michael F. ;

Profyris, Christos ;

Karnezis, Tara ;

Bernard, Claude C. ;

Small, David H. ;

Cheema, Surindar S. ;

Ozturk, Ezgi ;

Hatzinisiriou, Irene ;

Petratos, Steven .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (09) :914-929

[7] Leukemia inhibitory factor is expressed in astrocytes following cortical brain injury [J].

Banner, LR ;

Moayeri, NN ;

Patterson, PH .

EXPERIMENTAL NEUROLOGY, 1997, 147 (01) :1-9

[8]

Bauer S, 2003, J NEUROSCI, V23, P1792

[9] Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain [J].

Bauer, Sylvian ;

Patterson, Paul H. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (46) :12089-12099

[10] The origin and application of experimental autoimmune encephalomyelitis [J].

Baxter, Alan G. .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (11) :904-912

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