Seizures and altered mental status after lamotrigine overdose

被引：8

作者：

Schwartz, Michael D.

Geller, Robert J.

机构：

[1] ATSDR, Div Toxicol, PRMSB, Atlanta, GA 30333 USA

[2] Emory Univ, Georgia Poison Ctr, Div Toxicol, Atlanta, GA USA

来源：

THERAPEUTIC DRUG MONITORING | 2007年 / 29卷 / 06期

关键词：

lamotrigine; overdose; coma;

D O I：

10.1097/FTD.0b013e31815bf239

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Lamotrigine is a commonly prescribed anticonvulsant medication. It is an infrequently reported agent of intentional acute ingestion to poison centers. The spectra of clinical effects of lamotrigine in acute overdose are not well established. We report a case of acute ingestion of lamotrigine and ethanol that resulted in coma requiring ventilatory support, paradoxic seizure activity and mild rhabdomyolysis.

引用

页码：843 / 844

页数：2

共 9 条

[1] Lamotrigine in the treatment of bipolar disorder
Bhagwagar, Z
Goodwin, GM
[J]. EXPERT OPINION ON PHARMACOTHERAPY, 2005, 6 (08) : 1401 - 1408
[2] Lamotrigine childhood overdose
Briassoulis, G
Kalabalikis, P
Tamiolaki, M
Hatzis, T
[J]. PEDIATRIC NEUROLOGY, 1998, 19 (03) : 239 - 242
[3] BUCKLEY NA, 1993, LANCET, V342, P1452
[4] Lamotrigine distribution in two postmortem cases
Levine, B
Jufer, RA
Smialek, JE
[J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 2000, 24 (07) : 635 - 637
[5] Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome
Mylonakis, E
Vittorio, CC
Hollik, DA
Rounds, S
[J]. ANNALS OF PHARMACOTHERAPY, 1999, 33 (05) : 557 - 559
[6] Lamotrigine overdose in an adult
O'Donnell, J
Bateman, DN
[J]. JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2000, 38 (06): : 659 - 660
[7] Stupor from lamotrigine toxicity
Sbei, M
Campellone, JV
[J]. EPILEPSIA, 2001, 42 (08) : 1082 - 1083
[8] Stopforth J, 1997, S AFR MED J, V87, P1388
[9] Yatham LN, 2004, J CLIN PSYCHIAT, V65, P28

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