The origin and identity of embryonic stem cells

被引：151
作者：
Nichols, Jennifer [1 ,2 ]
Smith, Austin [1 ,3 ]
机构：
[1] Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 1QR, England
[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1QR, England
来源：
DEVELOPMENT | 2011年 / 138卷 / 01期
基金：
英国医学研究理事会;
关键词：
Cells; ES; Identity; PLURIPOTENT GROUND-STATE; PRIMORDIAL GERM-CELLS; MOUSE EGG-CYLINDERS; SELF-RENEWAL; PRIMITIVE ENDODERM; EXTRAUTERINE GROWTH; X-CHROMOSOME; LINES; DERIVATION; EPIBLAST;
D O I：
10.1242/dev.050831
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Embryonic stem (ES) cells are used extensively in biomedical research and as a model with which to study early mammalian development, but their exact origin has been subject to much debate. They are routinely derived from pre-implantation embryos, but it has been suggested that the cells that give rise to ES cells might arise from epiblast cells that are already predisposed to a primordial germ cell (PGC) fate, which then progress to ES cell status via the PGC lineage. Based on recent findings, we propose here that ES cells can be derived directly from early epiblast cells and that ES cells might arise via two different routes that are dictated by their culture conditions.
引用
收藏
页码：3 / 8
页数：6
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