Synthesis and Drug-Delivery Behavior of Chitosan-Functionalized Graphene Oxide Hybrid Nanosheets

被引：309
作者：
Rana, Vijay Kumar [1 ]
Choi, Myeon-Cheon [1 ]
Kong, Jin-Yeon [1 ]
Kim, Gwang Yeon [1 ]
Kim, Mi Ju [2 ]
Kim, Sun-Hee [2 ]
Mishra, Satyendra [3 ]
Singh, Raj Pal [4 ]
Ha, Chang-Sik [1 ]
机构：
[1] Pusan Natl Univ, Dept Polymer Sci & Engn, Pusan 609735, South Korea
[2] Pusan Natl Univ, Sch Med, Dept Biochem, Yangsan 626870, South Korea
[3] N Maharastra Univ, Dept Chem Technol, Jalgaon 425001, India
[4] Natl Chem Lab, Div Polymer Sci & Engn, Pune 411008, Maharashtra, India
来源：
MACROMOLECULAR MATERIALS AND ENGINEERING | 2011年 / 296卷 / 02期
关键词：
biocompatibility; chitosan; drug delivery systems; functionalization of polymers; solution properties; MULTIWALLED CARBON NANOTUBES; GRAPHITE OXIDE; RAMAN-SPECTRA; CHEMISTRY; STRENGTH;
D O I：
10.1002/mame.201000307
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Chitosan-functionalized graphene oxides (FGOCs) were successfully synthesized. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The presence of organic groups was confirmed by means of XPS and TGA. Restoration of the sp(2) carbon network and exfoliation of graphene sheets were confirmed by Raman spectroscopy, UV-visible spectroscopy and WAXD. The SEM and AFM investigations of the resultant FGOCs showed that most of the graphene sheets were individual and few were layered. Controlled release behavior of Ibuprofen and 5-fluorouracil was then investigated. We found that FGOCs are a promising new material for biological and medical applications.
引用
收藏
页码：131 / 140
页数：10
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