Functional proteins of mesenchymal stem cell-derived extracellular vesicles

被引：138
|
作者：
Qiu, Guanguan [1 ]
Zheng, Guoping [1 ]
Ge, Menghua [1 ]
Wang, Jiangmei [2 ]
Huang, Ruoqiong [2 ]
Shu, Qiang [2 ]
Xu, Jianguo [1 ,3 ]
机构：
[1] Shaoxing Second Hosp, 123 Yanan Rd, Shaoxing 312000, Zhejiang, Peoples R China
[2] Zhejiang Univ, Childrens Hosp, Sch Med, 3333 Binsheng Rd, Hangzhou 310051, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2019年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Mesenchymal stem; stromal cells; Extracellular vesicles; Exosomes; Microvesicles; Functional proteins; PROTEOMIC ANALYSIS; EXOSOME SECRETION; ANGIOGENESIS; BIOGENESIS; MODULATION; MICRORNA; RECOVERY; CATENIN;
D O I：
10.1186/s13287-019-1484-6
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.
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页数：11
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