Bioinspired Polymeric Nanocomposites for Regenerative Medicine

被引:109
作者
Carrow, James K. [1 ]
Gaharwar, Akhilesh K. [1 ,2 ]
机构
[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA
[2] Texas A&M Univ, Dept Mat Sci & Engn, College Stn, TX 77843 USA
关键词
bioinspired structures; hydrogels; nanomaterials; polymeric nanocomposites; tissue engineering; MESENCHYMAL STEM-CELLS; SIMULATED BODY-FLUID; TISSUE-ENGINEERING SCAFFOLDS; CROSS-LINKED PEO; MECHANICAL-PROPERTIES; OSTEOGENIC DIFFERENTIATION; BIOMEDICAL APPLICATIONS; SILICATE NANOPLATELETS; POLY(ETHYLENE GLYCOL); SURFACE MODIFICATION;
D O I
10.1002/macp.201400427
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The design and fabrication of bioinspired nanomaterials for tissue-engineering applications requires a fundamental understanding of the interactions between polymers, nanostructures, and cells. Most biomimetic polymeric nanocomposites consist of two or more types of polymers or of polymers combined with different nanomaterials to obtain composite structures with desired properties. In this Talents & Trends article, the focus is on bioinspired polymeric nanocomposites surrounding three major strategies. Firstly, biomimetic structures composed of a fibrous architecture are discussed. Secondly, the emerging trends in designing complex nanocomposites with multiple functionalities are assessed. Finally, some of the most critical challenges that come with the design and fabrication are highlighted in bioprinting. Finally, the emerging trends in the field of bioinspired polymeric nanocomposites are highlighted.
引用
收藏
页码:248 / 264
页数:17
相关论文
共 103 条
  • [1] Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms
    Agarwal, Rachit
    Singh, Vikramjit
    Jurney, Patrick
    Shi, Li
    Sreenivasan, S. V.
    Roy, Krishnendu
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (43) : 17247 - 17252
  • [2] Biodegradable polymer matrix nanocomposites for tissue engineering: A review
    Armentano, I.
    Dottori, M.
    Fortunati, E.
    Mattioli, S.
    Kenny, J. M.
    [J]. POLYMER DEGRADATION AND STABILITY, 2010, 95 (11) : 2126 - 2146
  • [3] Preparation of a biomimetic nanocomposite scaffold for bone tissue engineering via mineralization of gelatin hydrogel and study of mineral transformation in simulated body fluid
    Azami, Mahmoud
    Moosavifar, Mir Javad
    Baheiraei, Nafiseh
    Moztarzadeh, Fathollah
    Ai, Jafar
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012, 100A (05) : 1347 - 1355
  • [4] Fabrication of a bio-inspired beta-Tricalcium phosphate/collagen scaffold based on ceramic stereolithography and gel casting for osteochondral tissue engineering
    Bian, Weiguo
    Li, Dichen
    Lian, Qin
    Li, Xiang
    Zhang, Weijie
    Wang, Kunzheng
    Jin, Zhongmin
    [J]. RAPID PROTOTYPING JOURNAL, 2012, 18 (01) : 68 - 80
  • [5] Bixler GD, 2012, SOFT MATTER, V8, P12139
  • [6] Bio-inspired dicalcium phosphate anhydrate/poly(lactic acid) nanocomposite fibrous scaffolds for hard tissue regeneration: In situ synthesis and electrospinning
    Chae, Taesik
    Yang, Heejae
    Ko, Frank
    Troczynski, Tom
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (02) : 514 - 522
  • [7] Tissue engineering of cartilage using a hybrid scaffold of synthetic polymer and collagen
    Chen, GP
    Sato, T
    Ushida, T
    Ochiai, N
    Tateishi, T
    [J]. TISSUE ENGINEERING, 2004, 10 (3-4): : 323 - 330
  • [8] Computer-aided Design and Fabrication of Bio-mimetic Materials and Scaffold Micro-structures
    Chen, Yuhang
    Cadman, Joseph
    Zhou, Shiwei
    Li, Qing
    [J]. ADVANCED MATERIALS RESEARCH, 2011, 213 : 628 - 632
  • [9] Novel biologically-inspired rosette nanotube PLLA scaffolds for improving human mesenchymal stem cell chondrogenic differentiation
    Childs, Allie
    Hemraz, Usha D.
    Castro, Nathan J.
    Fenniri, Hicham
    Zhang, Lijie Grace
    [J]. BIOMEDICAL MATERIALS, 2013, 8 (06)
  • [10] The road ahead
    Cingolani, Roberto
    [J]. NATURE NANOTECHNOLOGY, 2013, 8 (11) : 792 - 793