Laser Doppler instrument to investigate retinal neural activity-induced changes in optic nerve head blood flow

被引:13
作者
Logean, E [1 ]
Geiser, MH
Riva, CE
机构
[1] Inst Rech Ophtalmol, CH-1950 Sion, Switzerland
[2] Haute Ecole Valaisanne, CH-1950 Sion, Switzerland
关键词
retinal neural activity; ocular circulation; laser Doppler flowmetry; optic nerve head; flicker stimulation;
D O I
10.1016/j.optlaseng.2004.04.011
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
A fundus camera-based instrument to investigate increased retinal neuronal activity effect on optic nerve blood flow is described. It incorporates (a) near infrared fundus illumination and observation, (b) near infrared laser Doppler flowmeter (LDF), (c) pupil position monitoring and (d) delivery of visual stimuli. Two types of stimulation are currently used: diffuse heterochromatic and chromatic luminance flicker generated by light emitting diodes, and contrast reversal pattern displayed on a video monitor. Recordings of the changes in the LDF parameters (blood velocity, volume and flow) from the optic nerve in response to these stimuli illustrate the potential of the technique. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:591 / 602
页数:12
相关论文
共 25 条
[1]  
American National Standards Institute, Z13612000 ANSI
[2]  
Bonner R. F., 1990, Principles of laser-Doppler Flowmetry, P17, DOI [10.1007/978-1-4757-2083-9_2, DOI 10.1007/978-1-4757-2083-9_2]
[3]  
Cummins H. Z., 1970, PROGRESS OPTICS, V8, P133
[4]   CONTINUOUS MEASUREMENT OF CEREBRAL CORTICAL BLOOD-FLOW BY LASER-DOPPLER FLOWMETRY IN A RAT STROKE MODEL [J].
DIRNAGL, U ;
KAPLAN, B ;
JACEWICZ, M ;
PULSINELLI, W .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (05) :589-596
[5]  
Falsini B, 2002, INVEST OPHTH VIS SCI, V43, P2309
[6]   Diffuse luminance flicker increases retinal vessel diameter in humans [J].
Formaz, F ;
Riva, CE ;
Geiser, M .
CURRENT EYE RESEARCH, 1997, 16 (12) :1252-1257
[7]   FUNCTIONAL ARCHITECTURE OF CORTEX REVEALED BY OPTICAL IMAGING OF INTRINSIC SIGNALS [J].
GRINVALD, A ;
LIEKE, E ;
FROSTIG, RD ;
GILBERT, CD ;
WIESEL, TN .
NATURE, 1986, 324 (6095) :361-364
[8]  
HARRISON JM, 1997, NONINVASIVE ASSESSME, P61
[9]   THE 1994 VONSALLMAN-LECTURE - THE OPTIC-NERVE HEAD CIRCULATION IN HEALTH AND DISEASE [J].
HAYREH, SS .
EXPERIMENTAL EYE RESEARCH, 1995, 61 (03) :259-272
[10]   How the retina works - Much of the construction of an image takes place in the retina itself through the use of specialized neural circuits [J].
Kolb, H .
AMERICAN SCIENTIST, 2003, 91 (01) :28-35