The Severity of Vestibular Dysfunction in Deafness as a Determinant of Comorbid Hyperactivity or Anxiety
被引:24
作者:
Antoine, Michelle W.
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机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Univ Calif Berkeley, Miller Inst Basic Res Sci, Berkeley, CA 94720 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Antoine, Michelle W.
[1
,3
]
论文数: 引用数:
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机构:
Vijayakumar, Sarath
[2
]
McKeehan, Nicholas
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
McKeehan, Nicholas
[1
]
Jones, Sherri M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nebraska Lincoln, Dept Special Educ & Commun Disorders, Lincoln, NE 68583 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Jones, Sherri M.
[2
]
Hebert, Jean M.
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h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Hebert, Jean M.
[1
]
机构:
[1] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
[2] Univ Nebraska Lincoln, Dept Special Educ & Commun Disorders, Lincoln, NE 68583 USA
[3] Univ Calif Berkeley, Miller Inst Basic Res Sci, Berkeley, CA 94720 USA
Attention-deficit/hyperactivity disorder (ADHD) and anxiety-related disorders occur at rates 2-3 times higher in deaf compared with hearing children. Potential explanations for these elevated rates and the heterogeneity of behavioral disorders associated with deafness have usually focused on socio-environmental rather than biological effects. Children with the 22q11.2 deletion or duplication syndromes often display hearing loss and behavioral disorders, including ADHD and anxiety-related disorders. Here, we show that mouse mutants with either a gain or loss of function of the T-Box transcription factor gene, Tbx1, which lies within the 22q11.2 region and is responsible for most of the syndromic defects, exhibit inner ear defects and hyperactivity. Furthermore, we show that (1) inner ear dysfunction due to the tissue-specific loss of Tbx1 or Slc12a2, which encodes a sodium-potassium-chloride cotransporter and is also necessary for inner ear function, causes hyperactivity; (2) vestibular rather than auditory failure causes hyperactivity; and (3) the severity rather than the age of onset of vestibular dysfunction differentiates whether hyperactivity or anxiety co-occurs with inner ear dysfunction. Together, these findings highlight a biological link between inner ear dysfunction and behavioral disorders and how sensory abnormalities can contribute to the etiology of disorders traditionally considered of cerebral origin.
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Antoine, Michelle W.
Huebner, Christian A.
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h-index: 0
机构:
Jena Univ Hosp, Inst Human Genet, D-07743 Jena, GermanyAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Huebner, Christian A.
Arezzo, Joseph C.
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h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Arezzo, Joseph C.
Hebert, Jean M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Antoine, Michelle W.
Huebner, Christian A.
论文数: 0引用数: 0
h-index: 0
机构:
Jena Univ Hosp, Inst Human Genet, D-07743 Jena, GermanyAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Huebner, Christian A.
Arezzo, Joseph C.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Arezzo, Joseph C.
Hebert, Jean M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA