The hypothalamic regulation of metabolic adaptations to exercise

被引：15
作者：
Fujikawa, T. [1 ,2 ]
Castorena, C. M. [1 ]
Lee, S. [1 ]
Elmquist, J. K. [1 ,3 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA
[2] Univ Texas Hlth San Antonio, Dept Cellular & Integrat Physiol, San Antonio, TX USA
[3] Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX USA
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2017年 / 29卷 / 10期
关键词：
energy expenditure; exercise; hypothalamus; metabolism; ventromedial hypothalamus; SENSITIVE K+ CHANNELS; GLUCOSE-SENSING NEURONS; BLOOD-BRAIN-BARRIER; ADULT-RAT BRAIN; CEREBROSPINAL-FLUID; PLASMA-MEMBRANE; GLUCOSE-TRANSPORTER-2; GLUT2; 5-HYDROXYINDOLEACETIC ACID; ENERGY HOMEOSTASIS; INHIBITED NEURONS;
D O I：
10.1111/jne.12533
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Our modern lifestyle is characterised by easy access to nutrient dense foods combined with limited physical activity. A sedentary lifestyle is one of several factors that have contributed to the global obesity epidemic and it also predisposes to chronic illnesses such as diabetes and cardiovascular disease. Although many studies have focused on the benefits of exercise in peripheral tissues, the contributions of the central nervous system to these exercise-induced metabolic adaptations are relatively unknown. The present review highlights the role of the ventromedial hypothalamus in regulating the metabolic response to exercise.
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页数：5
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