Cytoreductive surgery and HIPEC improve survival compared to palliative chemotherapy for biliary carcinoma with peritoneal metastasis: A multi-institutional cohort from PSOGI and BIG RENAPE groups

被引：25

作者：

Amblard, I ^{[1
,2
]}

Mercier, F. ^{[3
]}

Bartlett, D. L. ^{[4
]}

Ahrendt, S. A. ^{[4
]}

Lee, K. W. ^{[4
]}

Zeh, H. J. ^{[4
]}

Levine, E. A. ^{[5
]}

Baratti, D. ^{[6
]}

Deraco, M. ^{[6
]}

Piso, P. ^{[7
]}

Morris, D. L. ^{[8
]}

Rau, B. ^{[9
]}

Tentes, A. A. K. ^{[10
]}

Tuech, J-J ^{[11
]}

Quenet, F. ^{[12
]}

Akaishi, E. ^{[13
]}

Pocard, M. ^{[14
]}

Yonemura, Y. ^{[15
]}

Lorimier, G. ^{[16
]}

Delroeux, D. ^{[17
]}

Villeneuve, L. ^{[2
,18
]}

Glehen, O. ^{[1
,2
]}

Passot, G. ^{[1
,2
]}

机构：

[1] Hosp Civils Lyon, CHU Lyon Sud, Dept Surg Oncol, Lyon, France

[2] Univ Lyon 1, EMR 37-38, Villeurbanne, France

[3] Univ Montreal, Dept Surg Oncol, Montreal, PQ, Canada

[4] Univ Pittsburgh, Med Ctr, Shaydyside Hosp, Dept Surg, Pittsburg, KS USA

[5] Wake Forest Baptist Med Ctr, Dept Surg Sci Oncol, Winston Salem, NC USA

[6] Natl Canc Inst, Peritoneal Malignancy Program, Dept Surg, Milan, Italy

[7] Barmherzige Bruder Krankenhaus Regensburg, Dept Surg Oncol, Regensburg, Germany

[8] Univ New South Wales, Dept Surg, Sydney, Australia

[9] Univ Berlin, Virchow Klinikum, Dept Surg Oncol, Charite Campus, Berlin, Germany

[10] Didimotichon Gen Hosp, Dept Surg, Athens, Greece

[11] CHU Charles Nicolle, Dept Surg Oncol, Rouen, France

[12] Inst Canc Montpellier, Dept Surg Oncol, Montpellier, France

[13] Hosp Sirio Libanes, Dept Surg Oncol, Ctr Oncol, Sao Paulo, Brazil

[14] Hop Lariboisiere, Dept Surg Oncol, Paris, France

[15] Org Support Peritoneal Disseminat Treatment, Dept Surg Oncol, Osaka, Japan

[16] ICO Paul Papin, Dept Surg Oncol, Angers, France

[17] CHU Besancon, Dept Surg Oncol, Besancon, France

[18] Hosp Civils Lyon, Unite Rech Clin, Pole Informat Med Evaluat Rech, Lyon, France

来源：

EJSO | 2018年 / 44卷 / 09期

关键词：

Intra-hepatic cholangiocarcinoma; Gallbladder; Klatskin; Hilar cholangiocarcinoma; SURGICAL-TREATMENT; TRACT CANCER; CHOLANGIOCARCINOMA; GALLBLADDER; GEMCITABINE; THERAPY; ORIGIN;

D O I：

10.1016/j.ejso.2018.04.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Peritoneal metastasis from biliary carcinoma (PMC) is associated with poor prognosis when treated with chemotherapy. Objective: To evaluate the impact on survival of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), and compare with conventional palliative chemotherapy for patients with PMC. Material and methods: A prospective multicenter international database was retrospectively searched to identify all patients with PMC treated with a potentially curative CRS/HIPEC (CRS/HIPEC group). The overall survival (OS) was compared to patients with PMC treated with palliative chemotherapy (systemic chemotherapy group). Survival was analyzed using Kaplan-Meier method and compared with Log-Rank test. Results: Between 1995 and 2015, 34 patients were included in the surgical group, and compared to 21 in the systemic chemotherapy group. In the surgical group, median peritoneal cancer index was 9 (range 3 26), macroscopically complete resection was obtained for 25 patients (73%). There was more gallbladder localization in the surgical group compared to the chemotherapy group (35% vs. 18%, p = 0.001). Median OS was 21.4 and 9.3 months for surgical and chemotherapy group, respectively (p=0.007). Threeyear overall survival was 30% and 10% for surgical and chemotherapy group, respectively. Conclusion: Treatment with CRS and HIPEC for biliary carcinoma with peritoneal metastasis is feasible and may provide survival benefit when compared to palliative chemotherapy. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

引用

页码：1378 / 1383

页数：6

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