PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie

被引：41

作者：

Bossers, A ^{[1
]}

Harders, FL ^{[1
]}

Smits, MA ^{[1
]}

机构：

[1] DLO, Inst Anim Sci & Hlth, NL-8200 AB Lelystad, Netherlands

来源：

ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 04期

关键词：

D O I：

10.1007/s007050050548

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polymorphisms within the prion protein (PrP) gene are associated with scrapie susceptibility. We analysed the PrP genes of 140 Romney Marsh sheep, the dominant breed in New Zealand, a country free from scrapie. We found PrP alleles that are associated with a high susceptibility to scrapie. Sheep with these PrP genotypes would probably succumb to scrapie when born and raised in a scrapie endemic environment. These findings correspond to those obtained in minor breeds from New Zealand. We conclude that scrapie development not only depends on host genetic factors but also requires exogenous factors. Our findings demonstrate the effectiveness of the measures taken by New Zealand to maintain free from scrapie.

引用

页码：829 / 834

页数：6

共 15 条

[1] IDENTIFICATION OF 5 ALLELIC VARIANTS OF THE SHEEP PRP GENE AND THEIR ASSOCIATION WITH NATURAL SCRAPIE [J].

BELT, PBGM ;

MUILEMAN, IH ;

SCHREUDER, BEC ;

BOSDERUIJTER, J ;

GIELKENS, ALJ ;

SMITS, MA .

JOURNAL OF GENERAL VIROLOGY, 1995, 76 :509-517

[2] PrP genotype contributes to determining survival times of sheep with natural scrapie [J].

Bossers, A ;

Schreuder, BEC ;

Muileman, IH ;

Belt, PBGM ;

Smits, MA .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :2669-2673

[3] DIFFERENT ALLELIC EFFECTS OF THE CODON-136 AND CODON-171 OF THE PRION PROTEIN GENE IN SHEEP WITH NATURAL SCRAPIE [J].

CLOUSCARD, C ;

BEAUDRY, P ;

ELSEN, JM ;

MILAN, D ;

DUSSAUCY, M ;

BOUNNEAU, C ;

SCHELCHER, F ;

CHATELAIN, J ;

LAUNAY, JM ;

LAPLANCHE, JL .

JOURNAL OF GENERAL VIROLOGY, 1995, 76 :2097-2101

[4] Observations on the transmission of scrapie in experiments using embryo transfer [J].

Foster, JD ;

Hunter, N ;

Williams, A ;

Mylne, MJA ;

McKelvey, WAC ;

Hope, J ;

Fraser, H ;

Bostock, C .

VETERINARY RECORD, 1996, 138 (23) :559-562

[5] 2 ALLELES OF A NEURAL PROTEIN GENE LINKED TO SCRAPIE IN SHEEP [J].

GOLDMANN, W ;

HUNTER, N ;

FOSTER, JD ;

SALBAUM, JM ;

BEYREUTHER, K ;

HOPE, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2476-2480

[6] PRP GENOTYPE AND AGENT EFFECTS IN SCRAPIE - CHANGE IN ALLELIC INTERACTION WITH DIFFERENT ISOLATES OF AGENT IN SHEEP, A NATURAL HOST OF SCRAPIE [J].

GOLDMANN, W ;

HUNTER, N ;

SMITH, G ;

FOSTER, J ;

HOPE, J .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :989-995

[7] Is scrapie solely a genetic disease? [J].

Hunter, N ;

Cairns, D ;

Foster, JD ;

Smith, G ;

Goldmann, W ;

Donnelly, K .

NATURE, 1997, 386 (6621) :137-137

[8] SWALEDALE SHEEP AFFECTED BY NATURAL SCRAPIE DIFFER SIGNIFICANTLY IN PRP GENOTYPE FREQUENCIES FROM HEALTHY SHEEP AND THOSE SELECTED FOR REDUCED INCIDENCE OF SCRAPIE [J].

HUNTER, N ;

GOLDMANN, W ;

BENSON, G ;

FOSTER, JD ;

HOPE, J .

JOURNAL OF GENERAL VIROLOGY, 1993, 74 :1025-1031

[9] Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes [J].

Hunter, N ;

Foster, JD ;

Goldmann, W ;

Stear, MJ ;

Hope, J ;

Bostock, C .

ARCHIVES OF VIROLOGY, 1996, 141 (05) :809-824

[10] PRP POLYMORPHISMS ASSOCIATED WITH NATURAL SCRAPIE DISCOVERED BY DENATURING GRADIENT GEL-ELECTROPHORESIS [J].

LAPLANCHE, JL ;

CHATELAIN, J ;

WESTAWAY, D ;

THOMAS, S ;

DUSSAUCY, M ;

BRUGEREPICOUX, J ;

LAUNAY, JM .

GENOMICS, 1993, 15 (01) :30-37

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