Serum brain-derived neurotrophic factor levels associate with cognitive improvement in patients with schizophrenia treated with electroacupuncture

被引:20
作者
Sun, Zuo-Li [1 ]
Liu, Jie [1 ]
Guo, Wei [1 ]
Jiang, Tao [1 ]
Ma, Chao [1 ]
Li, Wen-Biao [1 ]
Tang, Yi-Lang [1 ,2 ]
Ling, Si-Hai [1 ]
机构
[1] Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
[2] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
关键词
Schizophrenia; Electroacupuncture; Cognitive deficit; BDNF; NEGATIVE SYMPTOMS; ACUPUNCTURE; BDNF; DEPRESSION; IMPAIRMENT; DEFICITS; EXPRESSION; MEMORY; BLIND;
D O I
10.1016/j.psychres.2016.07.040
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Accumulating evidence supports that acupuncture has been successfully used for the treatment of neurological disorders to improve cognitive function. This study was set to evaluate the efficacy of electroacupuncture (EA, using two acupoints: Baihui and Shenting) on clinical symptoms, cognitive function and brain-derived neurotrophic factor (BDNF) levels in patients with schizophrenia. Sixty-one inpatients diagnosed schizophrenia with DSM-IV criteria were recruited. The participants were randomly divided into an experimental group (n=30) and a control group (n=31). The patients were evaluated using the Positive and Negative Symptom Scale (PANSS), the Wisconsin Card Sorting Test (WCST) and Wechsler Memory Scale (WMS) at baseline and after EA treatment. There were no significant differences in the PANSS scores and serum BDNF levels between the experimental group and the control group, either at baseline or at the end of the 4-week study period. However, the EA treatment appeared to have significant benefits on memory and moderate benefits on executive functions and problem solving. Significant positive correlation was observed between the increase of BDNF levels and memory improvement after EA treatment. Our results indicated that EA treatment could improve cognitive function, and the cognitive benefits positively associate with serum BDNF levels in patients with schizophrenia. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:370 / 375
页数:6
相关论文
共 54 条
[1]   Scalp acupuncture effect on language development in children with autism: A pilot study [J].
Allam, Hemat ;
Eldine, Nirvana Gamal ;
Helmy, Ghada .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2008, 14 (02) :109-114
[2]  
[Anonymous], SLEEP DISORD
[3]  
[Anonymous], 2013, FRONT PSYCHIATRY
[4]  
[Anonymous], 2015, MEDICINE
[5]   Influence of atypical neuroleptics on executive functioning in patients with schizophrenia: a randomized, double-blind comparison of olanzapine vs. clozapine [J].
Bender, S ;
Dittmann-Balcar, A ;
Schall, U ;
Wolstein, J ;
Klimke, A ;
Riedel, M ;
Vorbach, EU ;
Kiihn, KU ;
Lambert, M ;
Dittmann, RW ;
Naber, D .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2006, 9 (02) :135-145
[6]   A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic amp-responsive transcription factor in the rat hippocampus [J].
Blanquet, PR ;
Mariani, J ;
Derer, P .
NEUROSCIENCE, 2003, 118 (02) :477-490
[7]   The effect of acupuncture on mood and working memory in patients with depression and schizophrenia [J].
Bosch, Peggy ;
van den Noort, Maurits ;
Yeo, Sujung ;
Lim, Sabina ;
Coenen, Anton ;
Van Luijtelaav, Gilles .
JOURNAL OF INTEGRATIVE MEDICINE-JIM, 2015, 13 (06) :380-390
[8]   SCHIZOPHRENIA AND DEPRESSION: A SYSTEMATIC REVIEW OF THE EFFECTIVENESS AND THE WORKING MECHANISMS BEHIND ACUPUNCTURE [J].
Bosch, Peggy ;
van den Noort, Maurits ;
Staudte, Heike ;
Lim, Sabina .
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING, 2015, 11 (04) :281-291
[9]   A case study on acupuncture in the treatment of schizophrenia [J].
Bosch, Peggy ;
Staudte, Heike ;
van den Noort, Maurits ;
Lim, Sabina .
ACUPUNCTURE IN MEDICINE, 2014, 32 (03) :286-289
[10]   Sleep Ameliorating Effects of Acupuncture in a Psychiatric Population [J].
Bosch, Peggy ;
van Luijtelaar, Gilles ;
van den Noort, Maurits ;
Lim, Sabina ;
Egger, Jos ;
Coenen, Anton .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013