Polylactides-Methods of synthesis and characterization

被引：145

作者：

Pretula, Julia ^{[1
]}

Slomkowski, Stanislaw ^{[1
]}

Penczek, Stanislaw ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Sienkiewicza 112, PL-90363 Lodz, Poland

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 107卷

关键词：

Polylactides; Polymerization of lactides; Polycondensation of lactic acid; Polylactide characterization; RING-OPENING POLYMERIZATION; POLY(L-LACTIC ACID); POLY(LACTIC ACID); CATIONIC-POLYMERIZATION; MECHANICAL-PROPERTIES; EPSILON-CAPROLACTONE; CRYSTAL-STRUCTURE; STEREOCOMPLEX FORMATION; ANIONIC-POLYMERIZATION; BETA-PROPIOLACTONE;

D O I：

10.1016/j.addr.2016.05.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polylactides with various molar masses, microstructures and crystallinities are used as degradable and biocompatible polymers suitable for preparation of drug carriers and temporary medical implants. This paper presents state of current knowledge on synthesis of lactic acids, high purity lactide monomers and their polymerization. Syntheses of high molar mass polylactides by polycondensation of lactic acid and by ring-opening polymerization of lactides are described and their advantages and disadvantages are discussed. Mechanisms of lactide polymerization initiated by metal alkoxides are described. There are presented also results of more recent studies of polymerization initiated with the so-called "no metal" organocatalysts; both anionic and cationic. Presented are advantages and limitations of synthesis of PLA by all the major polymerization processes until now. Some properties of PLA and most important methods used for PLA characterization are also described. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：3 / 16

页数：14

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