In Vivo Wireless Sensors for Gut Microbiome Redox Monitoring

被引：22

作者：

Baltsavias, Spyridon ^{[1
]}

Van Treuren, Will ^{[2
]}

Weber, Marcus J. ^{[1
]}

Charthad, Jayant ^{[1
]}

Baker, Sam ^{[3
]}

Sonnenburg, Justin L. ^{[2
]}

Arbabian, Amin ^{[1
]}

机构：

[1] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Comparat Med, Stanford, CA 94305 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2020年 / 67卷 / 07期

关键词：

Electrodes; Sensors; Implants; Electric potential; Biomedical measurement; Chemicals; In vivo; Implantable devices; implant sensors; wireless; redox potential; oxidation-reduction potential; ORP; gut; GI-tract; gastrointestinal; microbiome;

D O I：

10.1109/TBME.2019.2948575

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A perturbed gut microbiome has recently been linked with multiple disease processes, yet researchers currently lack tools that can provide in vivo, quantitative, and real-time insight into these processes and associated host-microbe interactions. We propose an in vivo wireless implant for monitoring gastrointestinal tract redox states using oxidation-reduction potentials (ORP). The implant is powered and conveniently interrogated via ultrasonic waves. We engineer the sensor electronics, electrodes, and encapsulation materials for robustness in vivo, and integrate them into an implant that endures autoclave sterilization and measures ORP for 12 days implanted in the cecum of a live rat. The presented implant platform paves the way for long-term experimental testing of biological hypotheses, offering new opportunities for understanding gut redox pathophysiology mechanisms, and facilitating translation to disease diagnosis and treatment applications.

引用

页码：1821 / 1830

页数：10

共 58 条

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