Tracking the origin, development, and differentiation of hematopoietic stem cells

被引:18
作者
Dharampuriya, Priyanka R. [1 ,2 ]
Scapin, Giorgia [1 ,2 ,3 ]
Wong, Colline [1 ,2 ,5 ]
Wagner, K. John [1 ,2 ,5 ]
Cillis, Jennifer L. [1 ,2 ,3 ]
Shah, Dhvanit I. [1 ,2 ,3 ,4 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA
[2] Harvard Stem Cell Inst, Cambridge, MA 02138 USA
[3] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02138 USA
[4] Dana Farber Harvard Canc Ctr, Boston, MA 02115 USA
[5] Boston Coll, Chestnut Hill, MA 02467 USA
关键词
CLONAL ANALYSIS; YOLK-SAC; B-CELL; PROGENITOR CELLS; T-LYMPHOCYTE; LINEAGE; EXPRESSION; REVEALS; SYSTEM; GENE;
D O I
10.1016/j.ceb.2018.01.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
This review chronicles the fate of the hematopoietic cells emerging from the mesoderm that subsequently develops into the adult blood lineages. Specifically, we explain classic techniques utilized in lineage tracing for the hematopoietic system, as well as novel state-of-the-art methods to elucidate clonal hematopoiesis and cell fate mapping at a single-cell level.
引用
收藏
页码:108 / 115
页数:8
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